Reformatsky Reaction of Ethyl 4-Chloro-4,4-difluorocrotonatePreparation of α-Substituted 4,4-Difluoro-3-butenoates

Takashi Tsukamoto, Tomoya Kitazume

Research output: Contribution to journalArticle

Abstract

Reformatsky reagent derived from ethyl 4-chloro-4, 4-difluorocrotonate was found to react with carbonyl compounds in the α-mode by using Zn-Cu couple to afford α-substituted 4,4-difluoro-3-butenoates.

Original languageEnglish (US)
Pages (from-to)977-979
Number of pages3
JournalSynlett
Volume1992
Issue number12
DOIs
StatePublished - Dec 1992

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ASJC Scopus subject areas

  • Organic Chemistry

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