Reformatsky Reaction of Ethyl 4-Chloro-4,4-difluorocrotonatePreparation of α-Substituted 4,4-Difluoro-3-butenoates

Takashi Tsukamoto; Tomoya Kitazume

doi:10.1055/s-1992-21552

Reformatsky Reaction of Ethyl 4-Chloro-4,4-difluorocrotonatePreparation of α-Substituted 4,4-Difluoro-3-butenoates

Takashi Tsukamoto, Tomoya Kitazume

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Abstract

Reformatsky reagent derived from ethyl 4-chloro-4, 4-difluorocrotonate was found to react with carbonyl compounds in the α-mode by using Zn-Cu couple to afford α-substituted 4,4-difluoro-3-butenoates.

Original language	English (US)
Pages (from-to)	977-979
Number of pages	3
Journal	Synlett
Volume	1992
Issue number	12
DOIs	https://doi.org/10.1055/s-1992-21552
State	Published - Dec 1992
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "Reformatsky Reaction of Ethyl 4-Chloro-4,4-difluorocrotonatePreparation of α-Substituted 4,4-Difluoro-3-butenoates",

abstract = "Reformatsky reagent derived from ethyl 4-chloro-4, 4-difluorocrotonate was found to react with carbonyl compounds in the α-mode by using Zn-Cu couple to afford α-substituted 4,4-difluoro-3-butenoates.",

author = "Takashi Tsukamoto and Tomoya Kitazume",

year = "1992",

month = dec,

doi = "10.1055/s-1992-21552",

language = "English (US)",

volume = "1992",

pages = "977--979",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "12",

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AU - Tsukamoto, Takashi

AU - Kitazume, Tomoya

PY - 1992/12

Y1 - 1992/12

N2 - Reformatsky reagent derived from ethyl 4-chloro-4, 4-difluorocrotonate was found to react with carbonyl compounds in the α-mode by using Zn-Cu couple to afford α-substituted 4,4-difluoro-3-butenoates.

AB - Reformatsky reagent derived from ethyl 4-chloro-4, 4-difluorocrotonate was found to react with carbonyl compounds in the α-mode by using Zn-Cu couple to afford α-substituted 4,4-difluoro-3-butenoates.

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DO - 10.1055/s-1992-21552

M3 - Article

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ER -

Reformatsky Reaction of Ethyl 4-Chloro-4,4-difluorocrotonatePreparation of α-Substituted 4,4-Difluoro-3-butenoates

Abstract

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