Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2

Ludmila Prokunina-Olsson, Yi Ping Fu, Wei Tang, Kevin B. Jacobs, Richard B. Hayes, Peter Kraft, Sonja I. Berndt, Sholom Wacholder, Kai Yu, Amy Hutchinson, Heather Spencer Feigelson, Michael J. Thun, W. Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R. Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri & 26 others Gerald L. Andriole, E. David Crawford, Christopher A. Haiman, Brian E. Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Ruth Travis, Rudolf Kaaks, William B Isaacs, Sarah D. Isaacs, Henrik Grönberg, Fredrik Wiklund, Jianfeng Xu, Lars J. Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Robert N. Hoover, Joseph F. Fraumeni, David J. Hunter, Gilles Thomas, Nilanjan Chatterjee, Stephen J. Chanock, Meredith Yeager

Research output: Contribution to journalArticle

Abstract

Background: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P = 2.14 × 10-6), with a suggestion of stronger association with aggressive disease (P = 1.2 x 10-7). Methods: In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry. Results: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P = 7.79 × 10-11; OR HET, 1.19 (95% confidence interval, 1.12-1.27); ORHOM, 1.37 (95% confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (P = 1.60 × 10-4 for aggressive cancer, n = 4,597; P = 3.25 x 10-8 for non-aggressive cancer, n = 4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in JAZF1 previously associated with height (rs849140; P = 0.587), body stature (rs849141, tagged by rs849136; P = 0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; P = 0.657). Conclusion: rs10486567 remains the most significant marker for PrCa risk within JAZF1 in individuals of European ancestry. Impact: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa.

Original languageEnglish (US)
Pages (from-to)1349-1355
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number5
DOIs
StatePublished - May 2010

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Prostatic Neoplasms
Chromosomes
Genes
Single Nucleotide Polymorphism
Genome-Wide Association Study
Confidence Intervals
Neoplasms
Linkage Disequilibrium
Genetic Predisposition to Disease
Genetic Markers
Systemic Lupus Erythematosus
Introns
Type 2 Diabetes Mellitus
Genome

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Prokunina-Olsson, L., Fu, Y. P., Tang, W., Jacobs, K. B., Hayes, R. B., Kraft, P., ... Yeager, M. (2010). Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2. Cancer Epidemiology Biomarkers and Prevention, 19(5), 1349-1355. https://doi.org/10.1158/1055-9965.EPI-09-1181

Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2. / Prokunina-Olsson, Ludmila; Fu, Yi Ping; Tang, Wei; Jacobs, Kevin B.; Hayes, Richard B.; Kraft, Peter; Berndt, Sonja I.; Wacholder, Sholom; Yu, Kai; Hutchinson, Amy; Feigelson, Heather Spencer; Thun, Michael J.; Diver, W. Ryan; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Schumacher, Fredrick R.; Cancel-Tassin, Geraldine; Cussenot, Olivier; Valeri, Antoine; Andriole, Gerald L.; Crawford, E. David; Haiman, Christopher A.; Henderson, Brian E.; Kolonel, Laurence; Le Marchand, Loic; Siddiq, Afshan; Riboli, Elio; Travis, Ruth; Kaaks, Rudolf; Isaacs, William B; Isaacs, Sarah D.; Grönberg, Henrik; Wiklund, Fredrik; Xu, Jianfeng; Vatten, Lars J.; Hveem, Kristian; Kumle, Merethe; Tucker, Margaret; Hoover, Robert N.; Fraumeni, Joseph F.; Hunter, David J.; Thomas, Gilles; Chatterjee, Nilanjan; Chanock, Stephen J.; Yeager, Meredith.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 19, No. 5, 05.2010, p. 1349-1355.

Research output: Contribution to journalArticle

Prokunina-Olsson, L, Fu, YP, Tang, W, Jacobs, KB, Hayes, RB, Kraft, P, Berndt, SI, Wacholder, S, Yu, K, Hutchinson, A, Feigelson, HS, Thun, MJ, Diver, WR, Albanes, D, Virtamo, J, Weinstein, S, Schumacher, FR, Cancel-Tassin, G, Cussenot, O, Valeri, A, Andriole, GL, Crawford, ED, Haiman, CA, Henderson, BE, Kolonel, L, Le Marchand, L, Siddiq, A, Riboli, E, Travis, R, Kaaks, R, Isaacs, WB, Isaacs, SD, Grönberg, H, Wiklund, F, Xu, J, Vatten, LJ, Hveem, K, Kumle, M, Tucker, M, Hoover, RN, Fraumeni, JF, Hunter, DJ, Thomas, G, Chatterjee, N, Chanock, SJ & Yeager, M 2010, 'Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2', Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 5, pp. 1349-1355. https://doi.org/10.1158/1055-9965.EPI-09-1181
Prokunina-Olsson, Ludmila ; Fu, Yi Ping ; Tang, Wei ; Jacobs, Kevin B. ; Hayes, Richard B. ; Kraft, Peter ; Berndt, Sonja I. ; Wacholder, Sholom ; Yu, Kai ; Hutchinson, Amy ; Feigelson, Heather Spencer ; Thun, Michael J. ; Diver, W. Ryan ; Albanes, Demetrius ; Virtamo, Jarmo ; Weinstein, Stephanie ; Schumacher, Fredrick R. ; Cancel-Tassin, Geraldine ; Cussenot, Olivier ; Valeri, Antoine ; Andriole, Gerald L. ; Crawford, E. David ; Haiman, Christopher A. ; Henderson, Brian E. ; Kolonel, Laurence ; Le Marchand, Loic ; Siddiq, Afshan ; Riboli, Elio ; Travis, Ruth ; Kaaks, Rudolf ; Isaacs, William B ; Isaacs, Sarah D. ; Grönberg, Henrik ; Wiklund, Fredrik ; Xu, Jianfeng ; Vatten, Lars J. ; Hveem, Kristian ; Kumle, Merethe ; Tucker, Margaret ; Hoover, Robert N. ; Fraumeni, Joseph F. ; Hunter, David J. ; Thomas, Gilles ; Chatterjee, Nilanjan ; Chanock, Stephen J. ; Yeager, Meredith. / Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2. In: Cancer Epidemiology Biomarkers and Prevention. 2010 ; Vol. 19, No. 5. pp. 1349-1355.
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abstract = "Background: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P = 2.14 × 10-6), with a suggestion of stronger association with aggressive disease (P = 1.2 x 10-7). Methods: In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry. Results: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P = 7.79 × 10-11; OR HET, 1.19 (95{\%} confidence interval, 1.12-1.27); ORHOM, 1.37 (95{\%} confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (P = 1.60 × 10-4 for aggressive cancer, n = 4,597; P = 3.25 x 10-8 for non-aggressive cancer, n = 4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in JAZF1 previously associated with height (rs849140; P = 0.587), body stature (rs849141, tagged by rs849136; P = 0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; P = 0.657). Conclusion: rs10486567 remains the most significant marker for PrCa risk within JAZF1 in individuals of European ancestry. Impact: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa.",
author = "Ludmila Prokunina-Olsson and Fu, {Yi Ping} and Wei Tang and Jacobs, {Kevin B.} and Hayes, {Richard B.} and Peter Kraft and Berndt, {Sonja I.} and Sholom Wacholder and Kai Yu and Amy Hutchinson and Feigelson, {Heather Spencer} and Thun, {Michael J.} and Diver, {W. Ryan} and Demetrius Albanes and Jarmo Virtamo and Stephanie Weinstein and Schumacher, {Fredrick R.} and Geraldine Cancel-Tassin and Olivier Cussenot and Antoine Valeri and Andriole, {Gerald L.} and Crawford, {E. David} and Haiman, {Christopher A.} and Henderson, {Brian E.} and Laurence Kolonel and {Le Marchand}, Loic and Afshan Siddiq and Elio Riboli and Ruth Travis and Rudolf Kaaks and Isaacs, {William B} and Isaacs, {Sarah D.} and Henrik Gr{\"o}nberg and Fredrik Wiklund and Jianfeng Xu and Vatten, {Lars J.} and Kristian Hveem and Merethe Kumle and Margaret Tucker and Hoover, {Robert N.} and Fraumeni, {Joseph F.} and Hunter, {David J.} and Gilles Thomas and Nilanjan Chatterjee and Chanock, {Stephen J.} and Meredith Yeager",
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TY - JOUR

T1 - Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2

AU - Prokunina-Olsson, Ludmila

AU - Fu, Yi Ping

AU - Tang, Wei

AU - Jacobs, Kevin B.

AU - Hayes, Richard B.

AU - Kraft, Peter

AU - Berndt, Sonja I.

AU - Wacholder, Sholom

AU - Yu, Kai

AU - Hutchinson, Amy

AU - Feigelson, Heather Spencer

AU - Thun, Michael J.

AU - Diver, W. Ryan

AU - Albanes, Demetrius

AU - Virtamo, Jarmo

AU - Weinstein, Stephanie

AU - Schumacher, Fredrick R.

AU - Cancel-Tassin, Geraldine

AU - Cussenot, Olivier

AU - Valeri, Antoine

AU - Andriole, Gerald L.

AU - Crawford, E. David

AU - Haiman, Christopher A.

AU - Henderson, Brian E.

AU - Kolonel, Laurence

AU - Le Marchand, Loic

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Travis, Ruth

AU - Kaaks, Rudolf

AU - Isaacs, William B

AU - Isaacs, Sarah D.

AU - Grönberg, Henrik

AU - Wiklund, Fredrik

AU - Xu, Jianfeng

AU - Vatten, Lars J.

AU - Hveem, Kristian

AU - Kumle, Merethe

AU - Tucker, Margaret

AU - Hoover, Robert N.

AU - Fraumeni, Joseph F.

AU - Hunter, David J.

AU - Thomas, Gilles

AU - Chatterjee, Nilanjan

AU - Chanock, Stephen J.

AU - Yeager, Meredith

PY - 2010/5

Y1 - 2010/5

N2 - Background: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P = 2.14 × 10-6), with a suggestion of stronger association with aggressive disease (P = 1.2 x 10-7). Methods: In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry. Results: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P = 7.79 × 10-11; OR HET, 1.19 (95% confidence interval, 1.12-1.27); ORHOM, 1.37 (95% confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (P = 1.60 × 10-4 for aggressive cancer, n = 4,597; P = 3.25 x 10-8 for non-aggressive cancer, n = 4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in JAZF1 previously associated with height (rs849140; P = 0.587), body stature (rs849141, tagged by rs849136; P = 0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; P = 0.657). Conclusion: rs10486567 remains the most significant marker for PrCa risk within JAZF1 in individuals of European ancestry. Impact: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa.

AB - Background: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P = 2.14 × 10-6), with a suggestion of stronger association with aggressive disease (P = 1.2 x 10-7). Methods: In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry. Results: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P = 7.79 × 10-11; OR HET, 1.19 (95% confidence interval, 1.12-1.27); ORHOM, 1.37 (95% confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (P = 1.60 × 10-4 for aggressive cancer, n = 4,597; P = 3.25 x 10-8 for non-aggressive cancer, n = 4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in JAZF1 previously associated with height (rs849140; P = 0.587), body stature (rs849141, tagged by rs849136; P = 0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; P = 0.657). Conclusion: rs10486567 remains the most significant marker for PrCa risk within JAZF1 in individuals of European ancestry. Impact: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa.

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