Refining the diagnoses of inattention and overactivity syndromes

A reanalysis of the Multimodal Treatment study of attention deficit hyperactivity disorder (ADHD) based on ICD-10 criteria for hyperkinetic disorder

Paramala J. Santosh, E. Taylor, J. Swanson, T. Wigal, S. Chuang, M. Davies, L. Greenhill, J. Newcorn, L. E. Arnold, P. Jensen, B. Vitiello, G. Elliott, S. Hinshaw, L. Hechtman, H. Abikoff, W. Pelham, B. Hoza, B. Molina, K. Wells, J. Epstein & 1 others M. Posner

Research output: Contribution to journalArticle

Abstract

There are large differences between nations in the diagnosis and management of children with marked impulsiveness and inattention. The differences extend to the names and definitions of disorder and the extent to which medication should be used. This paper uses data from a large randomized clinical trial of pharmacological and psychosocial treatments, conducted in North America, to clarify its implications for other parts of the world. A diagnostic algorithm was applied to 579 children, diagnosed with ADHD-Combined Type in the MTA trial, to generate the ICD-10 diagnosis of 'hyperkinetic disorder' (HD); only a quarter met these more stringent criteria. HD was a moderator of treatment response. The superiority of medication to behavioral treatment was greater for children with HD. Children with ADHD but not HD also showed some improvement with medication. The results provide evidence for the validity of HD as a subgroup of those presenting ADHD; and suggest that treatment with stimulants is a high priority in children with HD. Results also suggest that some children with other forms of ADHD will respond better to medication than to psychosocial intervention, and therefore that European guidelines should extend their indications.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalClinical Neuroscience Research
Volume5
Issue number5-6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Combined Modality Therapy
International Classification of Diseases
Attention Deficit Disorder with Hyperactivity
Pemetrexed
Therapeutics
North America
Names
Randomized Controlled Trials
Pharmacology
Guidelines

Keywords

  • Attention deficit\hyperactivity disorder
  • Hyperkinetic disorder
  • Nosology
  • Stimulant medication
  • Treatment guidelines

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Neuropsychology and Physiological Psychology

Cite this

Refining the diagnoses of inattention and overactivity syndromes : A reanalysis of the Multimodal Treatment study of attention deficit hyperactivity disorder (ADHD) based on ICD-10 criteria for hyperkinetic disorder. / Santosh, Paramala J.; Taylor, E.; Swanson, J.; Wigal, T.; Chuang, S.; Davies, M.; Greenhill, L.; Newcorn, J.; Arnold, L. E.; Jensen, P.; Vitiello, B.; Elliott, G.; Hinshaw, S.; Hechtman, L.; Abikoff, H.; Pelham, W.; Hoza, B.; Molina, B.; Wells, K.; Epstein, J.; Posner, M.

In: Clinical Neuroscience Research, Vol. 5, No. 5-6, 12.2005, p. 307-314.

Research output: Contribution to journalArticle

Santosh, PJ, Taylor, E, Swanson, J, Wigal, T, Chuang, S, Davies, M, Greenhill, L, Newcorn, J, Arnold, LE, Jensen, P, Vitiello, B, Elliott, G, Hinshaw, S, Hechtman, L, Abikoff, H, Pelham, W, Hoza, B, Molina, B, Wells, K, Epstein, J & Posner, M 2005, 'Refining the diagnoses of inattention and overactivity syndromes: A reanalysis of the Multimodal Treatment study of attention deficit hyperactivity disorder (ADHD) based on ICD-10 criteria for hyperkinetic disorder', Clinical Neuroscience Research, vol. 5, no. 5-6, pp. 307-314. https://doi.org/10.1016/j.cnr.2005.09.010
Santosh, Paramala J. ; Taylor, E. ; Swanson, J. ; Wigal, T. ; Chuang, S. ; Davies, M. ; Greenhill, L. ; Newcorn, J. ; Arnold, L. E. ; Jensen, P. ; Vitiello, B. ; Elliott, G. ; Hinshaw, S. ; Hechtman, L. ; Abikoff, H. ; Pelham, W. ; Hoza, B. ; Molina, B. ; Wells, K. ; Epstein, J. ; Posner, M. / Refining the diagnoses of inattention and overactivity syndromes : A reanalysis of the Multimodal Treatment study of attention deficit hyperactivity disorder (ADHD) based on ICD-10 criteria for hyperkinetic disorder. In: Clinical Neuroscience Research. 2005 ; Vol. 5, No. 5-6. pp. 307-314.
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