Refining the definition of hypereosinophilic syndrome

Hans Uwe Simon, Marc E. Rothenberg, Bruce S. Bochner, Peter F. Weller, Andrew J. Wardlaw, Michael E. Wechsler, Lanny J. Rosenwasser, Florence Roufosse, Gerald J. Gleich, Amy D. Klion

Research output: Contribution to journalArticlepeer-review


Because of advances in our understanding of the hypereosinophilic syndrome (HES) and the availability of novel therapeutic agents, the original criteria defining these disorders are becoming increasingly problematic. Here, we discuss shortcomings with the current definition of HES and recent developments in the classification of these disorders. Despite significant progress in our understanding of the pathogenesis of some forms of HES, the current state of knowledge is still insufficient to formulate a new comprehensive etiologic definition of HESs. Nevertheless, we suggest a new working definition that overcomes some of the most obvious limitations with the original definition.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Issue number1
StatePublished - Jul 2010
Externally publishedYes


  • Definition
  • eosinophilia
  • eosinophilic leukemia
  • hypereosinophilic syndromes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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