Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVβ4 as a candidate gene

Elizabeth P. Blankenhorn, Cheryl Descipio, Lucy Rodemich, Laura Cort, Jean H. Leif, Dale L. Greiner, John P. Mordes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC-identical normalWFrats, Iddm4d sensitively and specifically predicts induced diabetes. We report a new diabetes-susceptible subcongenic line that carries Iddm4 in a <2.6 megabase interval. Candidate genes include the T cell receptor β chain variable (TCRVβ) family. We found that TCRVβ4 in WF rats contains a stop codon, whereas 5/5 diabetes-susceptible rat strains express TCRVβ4. We conclude that Iddm4-mediated diabetes resistance in rats may be due to a recessive protective mutation in TCRVβ4.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages128-131
Number of pages4
Volume1103
DOIs
StatePublished - Apr 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1103
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • BB rat
  • Genetics
  • Iddm4
  • QTL
  • T cell receptor
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVβ4 as a candidate gene'. Together they form a unique fingerprint.

  • Cite this

    Blankenhorn, E. P., Descipio, C., Rodemich, L., Cort, L., Leif, J. H., Greiner, D. L., & Mordes, J. P. (2007). Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVβ4 as a candidate gene. In Annals of the New York Academy of Sciences (Vol. 1103, pp. 128-131). (Annals of the New York Academy of Sciences; Vol. 1103). https://doi.org/10.1196/annals.1394.020