Reference values of the mitral annular peak systolic velocity (Sm) in 690 healthy pediatric patients, calculation of Z-score values, and comparison to the mitral annular plane systolic excursion (MAPSE)

Martin Koestenberger, Bert Nagel, William Ravekes, Alexander Avian, Gerhard Cvirn, Thomas Rehak, Andreas Gamillscheg

Research output: Contribution to journalArticle

Abstract

Background: The mitral annular peak systolic velocity (Sm) is an echocardiographic measurement using tissue Doppler imaging to assess longitudinal left ventricular (LV) systolic function in children and adults. We determined growth-related changes in Sm to establish reference values for the entire pediatric age group. Methods and Results: A prospective study was conducted in a group of 690 healthy pediatric patients (age: 1 day-18 years). We determined the effects of age, sex, and body surface area (BSA) on the Sm values. Regression analysis was used to estimate Sm from age, BSA, and sex. In addition, a correlation of normal Sm with normal age-matched values of the M-mode parameter mitral annular plane systolic excursion (MAPSE) was measured. The Sm ranged from a mean of 5.8 cm/sec (Z-score ±2: 3.6-8.0 cm/sec) in the newborn to 11.8 cm/sec (Z-score ±2: 8.5-15.1 cm/sec) in the 18-year-old adolescent. The Sm values showed a positive correlation with age and BSA with a nonlinear course. There was no significant difference in Sm values between females and males. A significant correlation was found between Sm and MAPSE values. Conclusion: Z-scores of Sm values were calculated and percentile charts were established to serve as reference data in patients with congenital heart diseases. (Echocardiography 2014;31:1122-1130).

Original languageEnglish (US)
Pages (from-to)1122-1130
Number of pages9
JournalEchocardiography
Volume31
Issue number9
DOIs
StatePublished - Jan 1 2014

Keywords

  • Left ventricular systolic function
  • Mitral annular peak systolic velocity
  • Mitral annular plane systolic excursion
  • Pediatric patients
  • Reference values
  • Z-score

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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