Reference ranges for LVEF and LV volumes from electrocardiographically gated 82Rb cardiac PET/CT using commercially available software

Paco E. Bravo, David Chien, Mehrbod Som Som Javadi, Jennifer Merrill, Frank M. Bengel

Research output: Contribution to journalArticle

Abstract

Electrocardiographic gating is increasingly used for 82Rb cardiac PET/CT, but reference ranges for global functional parameters are not well defined. We sought to establish reference values for left ventricular ejection fraction (LVEF), end systolic volume (ESV), and end diastolic volume (EDV) using 4 different commercial software packages. Additionally, we compared 2 different approaches for the definition of a healthy individual. Methods: Sixty-two subjects (mean age ± SD, 49 ± 9 y; 85% women; mean body mass index ± SD, 34 ± 10 kg/m2) who underwent 82Rb-gated myocardial perfusion PET/CT were evaluated. All subjects had normal myocardial perfusion and no history of coronary artery disease (CAD) or cardiomyopathy. Subgroup 1 consisted of 34 individuals with low pretest probability of CAD (82Rb PET/CT varies significantly among available software programs and therefore cannot be used interchangeably. LVEF results were higher when healthy subjects were defined by a low pretest probability of CAD than by normal CT angiography results. COPYRIGHT

Original languageEnglish (US)
Pages (from-to)898-905
Number of pages8
JournalJournal of Nuclear Medicine
Volume51
Issue number6
DOIs
StatePublished - Jun 2010

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Stroke Volume
Coronary Artery Disease
Reference Values
Software
Perfusion
Cardiomyopathies
Healthy Volunteers
Body Mass Index
Computed Tomography Angiography

Keywords

  • Rb
  • Cardiac PET/CT
  • Electrocardiographic gating
  • Left ventricular ejection fraction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Reference ranges for LVEF and LV volumes from electrocardiographically gated 82Rb cardiac PET/CT using commercially available software. / Bravo, Paco E.; Chien, David; Javadi, Mehrbod Som Som; Merrill, Jennifer; Bengel, Frank M.

In: Journal of Nuclear Medicine, Vol. 51, No. 6, 06.2010, p. 898-905.

Research output: Contribution to journalArticle

Bravo, Paco E. ; Chien, David ; Javadi, Mehrbod Som Som ; Merrill, Jennifer ; Bengel, Frank M. / Reference ranges for LVEF and LV volumes from electrocardiographically gated 82Rb cardiac PET/CT using commercially available software. In: Journal of Nuclear Medicine. 2010 ; Vol. 51, No. 6. pp. 898-905.
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