Abstract
Two [18F]‐labelled analogues of dexetimide, a potent muscarinic cholinergic receptor ligand, have been synthesised in good yields and at high specific activities. Reductive amination of [2‐18F]‐ and [4‐18F]fluorobenzaldehyde with norbenzyldexetimide and sodium cyanoborohydride gave, in a one‐pot reaction, good (≈20%) yields of high specific activity [2‐18F]‐ and [4‐18F]fluorodexetimide respectively. The labelled benzaldehydes may be useful synthetic precursors for the radiosyntheses of other complex radiotracers for use with positron emission tomography.
Original language | English (US) |
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Pages (from-to) | 1189-1199 |
Number of pages | 11 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 28 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1990 |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry