Reductive amination of [18F]fluorobenzaldehydes: Radiosyntheses of [2‐18F]‐ and [4‐18F]fluorodexetimides

Alan A. Wilson, Robert F. Dannals, Hayden T. Ravert, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

Two [18F]‐labelled analogues of dexetimide, a potent muscarinic cholinergic receptor ligand, have been synthesised in good yields and at high specific activities. Reductive amination of [2‐18F]‐ and [4‐18F]fluorobenzaldehyde with norbenzyldexetimide and sodium cyanoborohydride gave, in a one‐pot reaction, good (≈20%) yields of high specific activity [2‐18F]‐ and [4‐18F]fluorodexetimide respectively. The labelled benzaldehydes may be useful synthetic precursors for the radiosyntheses of other complex radiotracers for use with positron emission tomography.

Original languageEnglish (US)
Pages (from-to)1189-1199
Number of pages11
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume28
Issue number10
DOIs
StatePublished - Oct 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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