Reductions in [3H]nicotinic acetylcholine binding in Alzheimer’s disease and Parkinson’s disease: An autoradiographic study

P. J. Whitehouse, A. M. Martino, M. V. Wagster, D. L. Price, R. Mayeux, J. R. Atack, K. J. Kellar

Research output: Contribution to journalArticlepeer-review

Abstract

In Alzheimer’s disease (AD) and Parkinson’s disease (PD), dysfunction in the basal forebrain cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers in cortex, but changes in cholinergic receptor binding sites are poorly understood. In the present study, we used receptor autoradiography to map the distribution of nicotinic [3H]acetylcholine binding sites in cortices of individuals with AD and PD and matched control subjects. In both diseases, a profound loss of nicotinic receptors occurs in all cortical layers, particularly the deepest layers.

Original languageEnglish (US)
Pages (from-to)720-723
Number of pages4
JournalNeurology
Volume38
Issue number5
DOIs
StatePublished - May 1988

ASJC Scopus subject areas

  • Clinical Neurology

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