Reductions in GABA following a tDCS-language intervention for primary progressive aphasia

Ashley D. Harris, Zeyi Wang, Bronte Ficek, Kimberly T Webster, Richard Anthony Edward Edden, Kyrana Tsapkini

Research output: Contribution to journalArticle

Abstract

Transcranial direct current stimulation (tDCS) has shown efficacy in augmenting the effects of language therapy in primary progressive aphasia (PPA). The mechanism of action of tDCS is not understood, but preliminary work in healthy adults suggests it modulates γ-aminobutyric acid (GABA) levels to create an environment optimal for learning. It is unknown if this proposed mechanism translates to aging or neurodegenerative conditions. This study tested the hypothesis that tDCS reduces GABA at the stimulated tissue in PPA. We applied GABA-edited magnetic resonance spectroscopy to quantify GABA levels before and after a sham-controlled tDCS intervention with language therapy in PPA. All participants showed improvements but those receiving active tDCS showed significantly greater language improvements compared to sham both immediately after the intervention and at 2-month follow-up. GABA levels in the targeted tissue decreased from baseline after the intervention and remained decreased 2 months after the intervention. This work supports the hypothesis that tDCS modulates GABAergic inhibition to augment learning and is clinically useful for PPA combined with language therapy.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalNeurobiology of Aging
Volume79
DOIs
StatePublished - Jul 1 2019

Fingerprint

Primary Progressive Aphasia
gamma-Aminobutyric Acid
Language
Language Therapy
Learning
Aminobutyrates
Transcranial Direct Current Stimulation
Magnetic Resonance Spectroscopy

Keywords

  • Anodal tDCS
  • GABA-edited MRS
  • Language therapy
  • Learning
  • Neural plasticity
  • Neurodegenerative disorder

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Reductions in GABA following a tDCS-language intervention for primary progressive aphasia. / Harris, Ashley D.; Wang, Zeyi; Ficek, Bronte; Webster, Kimberly T; Edden, Richard Anthony Edward; Tsapkini, Kyrana.

In: Neurobiology of Aging, Vol. 79, 01.07.2019, p. 75-82.

Research output: Contribution to journalArticle

@article{1f8bc125e31940de92607a54a3575805,
title = "Reductions in GABA following a tDCS-language intervention for primary progressive aphasia",
abstract = "Transcranial direct current stimulation (tDCS) has shown efficacy in augmenting the effects of language therapy in primary progressive aphasia (PPA). The mechanism of action of tDCS is not understood, but preliminary work in healthy adults suggests it modulates γ-aminobutyric acid (GABA) levels to create an environment optimal for learning. It is unknown if this proposed mechanism translates to aging or neurodegenerative conditions. This study tested the hypothesis that tDCS reduces GABA at the stimulated tissue in PPA. We applied GABA-edited magnetic resonance spectroscopy to quantify GABA levels before and after a sham-controlled tDCS intervention with language therapy in PPA. All participants showed improvements but those receiving active tDCS showed significantly greater language improvements compared to sham both immediately after the intervention and at 2-month follow-up. GABA levels in the targeted tissue decreased from baseline after the intervention and remained decreased 2 months after the intervention. This work supports the hypothesis that tDCS modulates GABAergic inhibition to augment learning and is clinically useful for PPA combined with language therapy.",
keywords = "Anodal tDCS, GABA-edited MRS, Language therapy, Learning, Neural plasticity, Neurodegenerative disorder",
author = "Harris, {Ashley D.} and Zeyi Wang and Bronte Ficek and Webster, {Kimberly T} and Edden, {Richard Anthony Edward} and Kyrana Tsapkini",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.neurobiolaging.2019.03.011",
language = "English (US)",
volume = "79",
pages = "75--82",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Reductions in GABA following a tDCS-language intervention for primary progressive aphasia

AU - Harris, Ashley D.

AU - Wang, Zeyi

AU - Ficek, Bronte

AU - Webster, Kimberly T

AU - Edden, Richard Anthony Edward

AU - Tsapkini, Kyrana

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Transcranial direct current stimulation (tDCS) has shown efficacy in augmenting the effects of language therapy in primary progressive aphasia (PPA). The mechanism of action of tDCS is not understood, but preliminary work in healthy adults suggests it modulates γ-aminobutyric acid (GABA) levels to create an environment optimal for learning. It is unknown if this proposed mechanism translates to aging or neurodegenerative conditions. This study tested the hypothesis that tDCS reduces GABA at the stimulated tissue in PPA. We applied GABA-edited magnetic resonance spectroscopy to quantify GABA levels before and after a sham-controlled tDCS intervention with language therapy in PPA. All participants showed improvements but those receiving active tDCS showed significantly greater language improvements compared to sham both immediately after the intervention and at 2-month follow-up. GABA levels in the targeted tissue decreased from baseline after the intervention and remained decreased 2 months after the intervention. This work supports the hypothesis that tDCS modulates GABAergic inhibition to augment learning and is clinically useful for PPA combined with language therapy.

AB - Transcranial direct current stimulation (tDCS) has shown efficacy in augmenting the effects of language therapy in primary progressive aphasia (PPA). The mechanism of action of tDCS is not understood, but preliminary work in healthy adults suggests it modulates γ-aminobutyric acid (GABA) levels to create an environment optimal for learning. It is unknown if this proposed mechanism translates to aging or neurodegenerative conditions. This study tested the hypothesis that tDCS reduces GABA at the stimulated tissue in PPA. We applied GABA-edited magnetic resonance spectroscopy to quantify GABA levels before and after a sham-controlled tDCS intervention with language therapy in PPA. All participants showed improvements but those receiving active tDCS showed significantly greater language improvements compared to sham both immediately after the intervention and at 2-month follow-up. GABA levels in the targeted tissue decreased from baseline after the intervention and remained decreased 2 months after the intervention. This work supports the hypothesis that tDCS modulates GABAergic inhibition to augment learning and is clinically useful for PPA combined with language therapy.

KW - Anodal tDCS

KW - GABA-edited MRS

KW - Language therapy

KW - Learning

KW - Neural plasticity

KW - Neurodegenerative disorder

UR - http://www.scopus.com/inward/record.url?scp=85064650044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064650044&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2019.03.011

DO - 10.1016/j.neurobiolaging.2019.03.011

M3 - Article

VL - 79

SP - 75

EP - 82

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -