Reductions in Acetylcholine and Nicotine Binding in Several Degenerative Diseases

Peter J. Whitehouse, Andrea M. Martino, Kendall A. Marcus, Richard M. Zweig, Harvey S. Singer, Donald L. Price, Kenneth J. Kellar

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimerʼs disease, Parkinsonʼs disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.

Original languageEnglish (US)
Pages (from-to)722-724
Number of pages3
JournalArchives of neurology
Volume45
Issue number7
DOIs
StatePublished - Jul 1988

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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