Alzheimerʼs disease, Parkinsonʼs disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.
|Original language||English (US)|
|Number of pages||3|
|Journal||Archives of neurology|
|State||Published - Jul 1988|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology