Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children

David M. Stoff, Leafy Pollock, Benedetto Vitiello, David Behar, Wagner H. Bridger

Research output: Contribution to journalArticlepeer-review

Abstract

Binding characteristics of tritiated imipramine on blood platelets were determined in daytime hospitalized prepubertal children who had mixed diagnoses of conduct disorder (CD) plus attention deficit disorder hyperactivity (ADDH) and in inpatient adolescents who had a history of aggressive behavior. The number of (3H)-imipramine maximal binding sites (Bmax) was significantly lower in the prepubertal patient group of CD plus ADDH; the dissociation constant (Kd) was not significantly different. There were significant negative correlations between Bmax and the Externalizing or Aggressive factors of the Child Behavior Checklist when the CD plus ADDH prepubertal patients were combined with their matched controls and within the adolescent inpatient group. We propose that a decreased platelet imipramine binding Bmaxvalue, as an index of disturbed presynaptic serotonergic activity, is not specific to depression and may be used as a biologic marker for the lack of behavioral constraint in heterogeneous populations of psychiatric patients.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalNeuropsychopharmacology
Volume1
Issue number1
DOIs
StatePublished - Dec 1987

Keywords

  • (H)-imipramine binding
  • Aggression
  • Conduct disorder
  • Impulsivity
  • Platelets
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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