Reduction of neonatal tetanus by mass immunization of non-pregnant women: Duration of protection provided by one or two doses of aluminium-adsorbed tetanus toxoid

R. E. Black, D. H. Huber, G. T. Curlin

Research output: Contribution to journalArticlepeer-review

Abstract

Immunization of non-pregnant women in rural Bangladesh with two doses of aluminium-adsorbed tetanus-diphtheria toxoids reduced neonatal mortality by one-third during a period of 9-32 months after vaccination. The reduction in mortality rate was attributable almost entirely to a 75% lower mortality rate among 4- to 14-day-old infants, when tetanus was the predominant cause of death. In the period up to 20 months following vaccination, the reduction in deaths among 4- to 14-day-old infants after a single dose of tetanus-diphtheria toxoids was about the same as that after two doses. However, beyond 20 months a single dose did not appear to provide protection.

Original languageEnglish (US)
Pages (from-to)927-930
Number of pages4
JournalBulletin of the World Health Organization
Volume58
Issue number6
StatePublished - Dec 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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