Abstract
Background Antibiotics used to reduce nasal colonization by Staphylococcus aureus in patients before admission are inappropriate for carriage reduction on a regular basis within a hospital community. Effective nonantibiotic alternatives for daily use in the nares will allow reduction of this bacterial source to be addressed. Methods Our study tested the effectiveness of a nonantibiotic, alcohol-based antiseptic in reducing nasal bacterial carriage in health care professionals (HCPs) at an urban hospital center. HCPs testing positive for vestibular S aureus colonization were treated 3 times during the day with topical antiseptic or control preparations. Nasal S aureus and total bacterial colonization levels were determined before and at the end of a 10-hour workday. Results Seventy-eight of 387 HCPs screened (20.2%) tested positive for S aureus infection. Of 39 subjects who tested positive for S aureus infection who completed the study, 20 received antiseptic and 19 received placebo treatment. Antiseptic treatment reduced S aureus colony forming units from baseline by 99% (median) and 82% (mean) (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 841-846 |
| Number of pages | 6 |
| Journal | American Journal of Infection Control |
| Volume | 42 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Bacterial burden
- Ethanol
- Infection control
- Nasal colonization
ASJC Scopus subject areas
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- Epidemiology
- Health Policy
- Medicine(all)
Cite this
Reduction of nasal Staphylococcus aureus carriage in health care professionals by treatment with a nonantibiotic, alcohol-based nasal antiseptic. / Steed, Lisa L.; Costello, Justin; Lohia, Shivangi; Jones, Taylor; Spannhake, Ernst W; Nguyen, Shaun.
In: American Journal of Infection Control, Vol. 42, No. 8, 2014, p. 841-846.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduction of nasal Staphylococcus aureus carriage in health care professionals by treatment with a nonantibiotic, alcohol-based nasal antiseptic
AU - Steed, Lisa L.
AU - Costello, Justin
AU - Lohia, Shivangi
AU - Jones, Taylor
AU - Spannhake, Ernst W
AU - Nguyen, Shaun
PY - 2014
Y1 - 2014
N2 - Background Antibiotics used to reduce nasal colonization by Staphylococcus aureus in patients before admission are inappropriate for carriage reduction on a regular basis within a hospital community. Effective nonantibiotic alternatives for daily use in the nares will allow reduction of this bacterial source to be addressed. Methods Our study tested the effectiveness of a nonantibiotic, alcohol-based antiseptic in reducing nasal bacterial carriage in health care professionals (HCPs) at an urban hospital center. HCPs testing positive for vestibular S aureus colonization were treated 3 times during the day with topical antiseptic or control preparations. Nasal S aureus and total bacterial colonization levels were determined before and at the end of a 10-hour workday. Results Seventy-eight of 387 HCPs screened (20.2%) tested positive for S aureus infection. Of 39 subjects who tested positive for S aureus infection who completed the study, 20 received antiseptic and 19 received placebo treatment. Antiseptic treatment reduced S aureus colony forming units from baseline by 99% (median) and 82% (mean) (P
AB - Background Antibiotics used to reduce nasal colonization by Staphylococcus aureus in patients before admission are inappropriate for carriage reduction on a regular basis within a hospital community. Effective nonantibiotic alternatives for daily use in the nares will allow reduction of this bacterial source to be addressed. Methods Our study tested the effectiveness of a nonantibiotic, alcohol-based antiseptic in reducing nasal bacterial carriage in health care professionals (HCPs) at an urban hospital center. HCPs testing positive for vestibular S aureus colonization were treated 3 times during the day with topical antiseptic or control preparations. Nasal S aureus and total bacterial colonization levels were determined before and at the end of a 10-hour workday. Results Seventy-eight of 387 HCPs screened (20.2%) tested positive for S aureus infection. Of 39 subjects who tested positive for S aureus infection who completed the study, 20 received antiseptic and 19 received placebo treatment. Antiseptic treatment reduced S aureus colony forming units from baseline by 99% (median) and 82% (mean) (P
KW - Bacterial burden
KW - Ethanol
KW - Infection control
KW - Nasal colonization
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UR - http://www.scopus.com/inward/citedby.url?scp=84905575809&partnerID=8YFLogxK
U2 - 10.1016/j.ajic.2014.04.008
DO - 10.1016/j.ajic.2014.04.008
M3 - Article
C2 - 24881497
AN - SCOPUS:84905575809
VL - 42
SP - 841
EP - 846
JO - American Journal of Infection Control
JF - American Journal of Infection Control
SN - 0196-6553
IS - 8
ER -