Reduction of IgG Levels in Myasthenia

Allen R. Nissenson, Daniel B. Drachman, Ing Kao, Alan Pestronk, Diane Griffin, Jerry A. Winkelstein

Research output: Contribution to journalLetterpeer-review


To the Editor: Further clarification of the possible autoimmune nature of myasthenia gravis is presented in a recent Journal article by Toyka et al.1 and extends previous work by the same investigators2 and others.3 Implications for therapy, however, are not nearly as clear. The role of corticosteroids in the treatment of this disorder remains controversial, and the myriad side effects of these potent compounds are well known. If an analogy is drawn between the beneficial effects of lowering serum antibody levels in glomerulonephritis associated with circulating anti-glomerular-basement-membrane antibodies4 and the potential benefit of lowering immunoglobulin levels in myasthenia gravis,.

Original languageEnglish (US)
Pages (from-to)819-820
Number of pages2
JournalNew England Journal of Medicine
Issue number14
StatePublished - Apr 7 1977

ASJC Scopus subject areas

  • Medicine(all)


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