Abstract
Baboons responded on a discrete-trial choice task on which trials occurred every three hours throughout the day. Trials involved choosing between several mutually exclusive options, one of which was always associated with intravenous infusion of a unit dose of heroin. Experiments were undertaken to reduce the selection of the heroin option. Experiment 1 used methods analogous to clinical situations involving opioid maintenance and subsequent detoxification. During initial baseline conditions, baboons consistently preferred an option of heroin and food over an option of saline and food. Selection of heroin was almost entirely eliminated when there was a mutually exclusive choice between heroin and food and chronic non-contingent morphine was administered. Decreasing the dose of non-contingent morphine produced an increased selection of heroin. In Experiment 2, initial baseline conditions were similar to Experiment 1. Food availability was subsequently made contingent upon selection of options involving progressively lower doses of contingent heroin. These manipulations reduced heroin intake to about 15% of baseline levels. The experiments demonstrate the utility of animal models for studying procedures for the reduction of opiate self-administration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 519-528 |
| Number of pages | 10 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1977 |
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Keywords
- Animal models
- Choice procedure
- Drug self-administration
- Heroin
- Morphine
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Reduction of heroin self-administration in baboons by manipulation of behavioral and pharmacological conditions. / Wurster, Richard M.; Griffiths, Roland R; Findley, Jack D.; Brady, Joseph V.
In: Pharmacology Biochemistry and Behavior, Vol. 7, No. 6, 1977, p. 519-528.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduction of heroin self-administration in baboons by manipulation of behavioral and pharmacological conditions
AU - Wurster, Richard M.
AU - Griffiths, Roland R
AU - Findley, Jack D.
AU - Brady, Joseph V.
PY - 1977
Y1 - 1977
N2 - Baboons responded on a discrete-trial choice task on which trials occurred every three hours throughout the day. Trials involved choosing between several mutually exclusive options, one of which was always associated with intravenous infusion of a unit dose of heroin. Experiments were undertaken to reduce the selection of the heroin option. Experiment 1 used methods analogous to clinical situations involving opioid maintenance and subsequent detoxification. During initial baseline conditions, baboons consistently preferred an option of heroin and food over an option of saline and food. Selection of heroin was almost entirely eliminated when there was a mutually exclusive choice between heroin and food and chronic non-contingent morphine was administered. Decreasing the dose of non-contingent morphine produced an increased selection of heroin. In Experiment 2, initial baseline conditions were similar to Experiment 1. Food availability was subsequently made contingent upon selection of options involving progressively lower doses of contingent heroin. These manipulations reduced heroin intake to about 15% of baseline levels. The experiments demonstrate the utility of animal models for studying procedures for the reduction of opiate self-administration.
AB - Baboons responded on a discrete-trial choice task on which trials occurred every three hours throughout the day. Trials involved choosing between several mutually exclusive options, one of which was always associated with intravenous infusion of a unit dose of heroin. Experiments were undertaken to reduce the selection of the heroin option. Experiment 1 used methods analogous to clinical situations involving opioid maintenance and subsequent detoxification. During initial baseline conditions, baboons consistently preferred an option of heroin and food over an option of saline and food. Selection of heroin was almost entirely eliminated when there was a mutually exclusive choice between heroin and food and chronic non-contingent morphine was administered. Decreasing the dose of non-contingent morphine produced an increased selection of heroin. In Experiment 2, initial baseline conditions were similar to Experiment 1. Food availability was subsequently made contingent upon selection of options involving progressively lower doses of contingent heroin. These manipulations reduced heroin intake to about 15% of baseline levels. The experiments demonstrate the utility of animal models for studying procedures for the reduction of opiate self-administration.
KW - Animal models
KW - Choice procedure
KW - Drug self-administration
KW - Heroin
KW - Morphine
UR - http://www.scopus.com/inward/record.url?scp=0017593031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017593031&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(77)90248-9
DO - 10.1016/0091-3057(77)90248-9
M3 - Article
C2 - 413116
AN - SCOPUS:0017593031
VL - 7
SP - 519
EP - 528
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
SN - 0091-3057
IS - 6
ER -