Reduction of heroin self-administration in baboons by manipulation of behavioral and pharmacological conditions

Richard M. Wurster, Roland R Griffiths, Jack D. Findley, Joseph V. Brady

Research output: Contribution to journalArticle

Abstract

Baboons responded on a discrete-trial choice task on which trials occurred every three hours throughout the day. Trials involved choosing between several mutually exclusive options, one of which was always associated with intravenous infusion of a unit dose of heroin. Experiments were undertaken to reduce the selection of the heroin option. Experiment 1 used methods analogous to clinical situations involving opioid maintenance and subsequent detoxification. During initial baseline conditions, baboons consistently preferred an option of heroin and food over an option of saline and food. Selection of heroin was almost entirely eliminated when there was a mutually exclusive choice between heroin and food and chronic non-contingent morphine was administered. Decreasing the dose of non-contingent morphine produced an increased selection of heroin. In Experiment 2, initial baseline conditions were similar to Experiment 1. Food availability was subsequently made contingent upon selection of options involving progressively lower doses of contingent heroin. These manipulations reduced heroin intake to about 15% of baseline levels. The experiments demonstrate the utility of animal models for studying procedures for the reduction of opiate self-administration.

Original languageEnglish (US)
Pages (from-to)519-528
Number of pages10
JournalPharmacology Biochemistry and Behavior
Volume7
Issue number6
DOIs
StatePublished - 1977

Fingerprint

Behavior Control
Self Administration
Papio
Heroin
Pharmacology
Food
Experiments
Morphine
Opiate Alkaloids
Detoxification
Intravenous Infusions
Opioid Analgesics
Animals
Animal Models
Availability

Keywords

  • Animal models
  • Choice procedure
  • Drug self-administration
  • Heroin
  • Morphine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Reduction of heroin self-administration in baboons by manipulation of behavioral and pharmacological conditions. / Wurster, Richard M.; Griffiths, Roland R; Findley, Jack D.; Brady, Joseph V.

In: Pharmacology Biochemistry and Behavior, Vol. 7, No. 6, 1977, p. 519-528.

Research output: Contribution to journalArticle

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