Reduction of conditioned pain modulation in humans by naltrexone: An exploratory study of the effects of pain catastrophizing

Christopher D. King, Burel Goodin, Lindsay L. Kindler, Robert M. Caudle, Robert R. Edwards, Nikolaus Gravenstein, Joseph L. Riley, Roger B. Fillingim

Research output: Contribution to journalArticle

Abstract

The current study tested the hypothesis that conditioned pain modulation is mediated by the release of endogenous opioids with a placebo-controlled (sugar pill) study of naltrexone (50 mg) in 33 healthy volunteers over two counter-balanced sessions. Pain modulation consisted of rating of heat pain (palm) during concurrent cold water immersion (foot). Compared to baseline heat pain ratings, concurrent foot immersion lowered pain intensity ratings, which suggests an inhibitory effect, was reduced with naltrexone, suggesting at least partial dependence of inhibition on endogenous opioids. An exploratory analysis revealed that individual differences in catastrophizing moderated the effects of naltrexone; endogenous opioid blockade abolished modulation in subjects lower in catastrophizing while modulation was unaffected by naltrexone among high catastrophizers. The results suggest a role of endogenous opioids in endogenous analgesia, but hint that multiple systems might contribute to conditioned pain modulation, and that these systems might be differentially activated as a function of individual differences in responses to pain.

Original languageEnglish (US)
Pages (from-to)315-327
Number of pages13
JournalJournal of Behavioral Medicine
Volume36
Issue number3
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Catastrophization
Naltrexone
Pain
Opioid Analgesics
Immersion Foot
Individuality
Hot Temperature
Analgesia
Healthy Volunteers
Placebos
Water

Keywords

  • Catastrophizing
  • Conditioned pain modulation
  • Diffuse noxious inhibitory control
  • Endogenous opioids
  • Heat pain
  • Naltrexone

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health

Cite this

King, C. D., Goodin, B., Kindler, L. L., Caudle, R. M., Edwards, R. R., Gravenstein, N., ... Fillingim, R. B. (2013). Reduction of conditioned pain modulation in humans by naltrexone: An exploratory study of the effects of pain catastrophizing. Journal of Behavioral Medicine, 36(3), 315-327. https://doi.org/10.1007/s10865-012-9424-2

Reduction of conditioned pain modulation in humans by naltrexone : An exploratory study of the effects of pain catastrophizing. / King, Christopher D.; Goodin, Burel; Kindler, Lindsay L.; Caudle, Robert M.; Edwards, Robert R.; Gravenstein, Nikolaus; Riley, Joseph L.; Fillingim, Roger B.

In: Journal of Behavioral Medicine, Vol. 36, No. 3, 06.2013, p. 315-327.

Research output: Contribution to journalArticle

King, CD, Goodin, B, Kindler, LL, Caudle, RM, Edwards, RR, Gravenstein, N, Riley, JL & Fillingim, RB 2013, 'Reduction of conditioned pain modulation in humans by naltrexone: An exploratory study of the effects of pain catastrophizing', Journal of Behavioral Medicine, vol. 36, no. 3, pp. 315-327. https://doi.org/10.1007/s10865-012-9424-2
King, Christopher D. ; Goodin, Burel ; Kindler, Lindsay L. ; Caudle, Robert M. ; Edwards, Robert R. ; Gravenstein, Nikolaus ; Riley, Joseph L. ; Fillingim, Roger B. / Reduction of conditioned pain modulation in humans by naltrexone : An exploratory study of the effects of pain catastrophizing. In: Journal of Behavioral Medicine. 2013 ; Vol. 36, No. 3. pp. 315-327.
@article{365eb21e24384a11895aeb24b6be709d,
title = "Reduction of conditioned pain modulation in humans by naltrexone: An exploratory study of the effects of pain catastrophizing",
abstract = "The current study tested the hypothesis that conditioned pain modulation is mediated by the release of endogenous opioids with a placebo-controlled (sugar pill) study of naltrexone (50 mg) in 33 healthy volunteers over two counter-balanced sessions. Pain modulation consisted of rating of heat pain (palm) during concurrent cold water immersion (foot). Compared to baseline heat pain ratings, concurrent foot immersion lowered pain intensity ratings, which suggests an inhibitory effect, was reduced with naltrexone, suggesting at least partial dependence of inhibition on endogenous opioids. An exploratory analysis revealed that individual differences in catastrophizing moderated the effects of naltrexone; endogenous opioid blockade abolished modulation in subjects lower in catastrophizing while modulation was unaffected by naltrexone among high catastrophizers. The results suggest a role of endogenous opioids in endogenous analgesia, but hint that multiple systems might contribute to conditioned pain modulation, and that these systems might be differentially activated as a function of individual differences in responses to pain.",
keywords = "Catastrophizing, Conditioned pain modulation, Diffuse noxious inhibitory control, Endogenous opioids, Heat pain, Naltrexone",
author = "King, {Christopher D.} and Burel Goodin and Kindler, {Lindsay L.} and Caudle, {Robert M.} and Edwards, {Robert R.} and Nikolaus Gravenstein and Riley, {Joseph L.} and Fillingim, {Roger B.}",
year = "2013",
month = "6",
doi = "10.1007/s10865-012-9424-2",
language = "English (US)",
volume = "36",
pages = "315--327",
journal = "Journal of Behavioral Medicine",
issn = "0160-7715",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Reduction of conditioned pain modulation in humans by naltrexone

T2 - An exploratory study of the effects of pain catastrophizing

AU - King, Christopher D.

AU - Goodin, Burel

AU - Kindler, Lindsay L.

AU - Caudle, Robert M.

AU - Edwards, Robert R.

AU - Gravenstein, Nikolaus

AU - Riley, Joseph L.

AU - Fillingim, Roger B.

PY - 2013/6

Y1 - 2013/6

N2 - The current study tested the hypothesis that conditioned pain modulation is mediated by the release of endogenous opioids with a placebo-controlled (sugar pill) study of naltrexone (50 mg) in 33 healthy volunteers over two counter-balanced sessions. Pain modulation consisted of rating of heat pain (palm) during concurrent cold water immersion (foot). Compared to baseline heat pain ratings, concurrent foot immersion lowered pain intensity ratings, which suggests an inhibitory effect, was reduced with naltrexone, suggesting at least partial dependence of inhibition on endogenous opioids. An exploratory analysis revealed that individual differences in catastrophizing moderated the effects of naltrexone; endogenous opioid blockade abolished modulation in subjects lower in catastrophizing while modulation was unaffected by naltrexone among high catastrophizers. The results suggest a role of endogenous opioids in endogenous analgesia, but hint that multiple systems might contribute to conditioned pain modulation, and that these systems might be differentially activated as a function of individual differences in responses to pain.

AB - The current study tested the hypothesis that conditioned pain modulation is mediated by the release of endogenous opioids with a placebo-controlled (sugar pill) study of naltrexone (50 mg) in 33 healthy volunteers over two counter-balanced sessions. Pain modulation consisted of rating of heat pain (palm) during concurrent cold water immersion (foot). Compared to baseline heat pain ratings, concurrent foot immersion lowered pain intensity ratings, which suggests an inhibitory effect, was reduced with naltrexone, suggesting at least partial dependence of inhibition on endogenous opioids. An exploratory analysis revealed that individual differences in catastrophizing moderated the effects of naltrexone; endogenous opioid blockade abolished modulation in subjects lower in catastrophizing while modulation was unaffected by naltrexone among high catastrophizers. The results suggest a role of endogenous opioids in endogenous analgesia, but hint that multiple systems might contribute to conditioned pain modulation, and that these systems might be differentially activated as a function of individual differences in responses to pain.

KW - Catastrophizing

KW - Conditioned pain modulation

KW - Diffuse noxious inhibitory control

KW - Endogenous opioids

KW - Heat pain

KW - Naltrexone

UR - http://www.scopus.com/inward/record.url?scp=84875344583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875344583&partnerID=8YFLogxK

U2 - 10.1007/s10865-012-9424-2

DO - 10.1007/s10865-012-9424-2

M3 - Article

C2 - 22534819

AN - SCOPUS:84875344583

VL - 36

SP - 315

EP - 327

JO - Journal of Behavioral Medicine

JF - Journal of Behavioral Medicine

SN - 0160-7715

IS - 3

ER -