Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats

Ellen E. Ladenheim, Robert C. Speth, Robert C. Ritter

Research output: Contribution to journalArticlepeer-review

Abstract

Cholecystokinin octapeptide (CCK-8) binding sites were examined in the caudal hindbrain of unilaterally nodosectomized and intact rats by in vitro autoradiography with 125I-CCK-8. Unilateral nodosectomy caused a significant reduction in CCK-8 binding in the caudal medial nucleus of the solitary tract (NST) on the side ipsilateratal to the node gangliosectomy. Examination of other caudal hindbrain regions exhibiting CCK-8 binding did not reveal changes in binding in nodosectomized animals compared to controls. These findings suggest that the CCK receptors in this brain region may be located on terminals of vagal afferent neurons.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalBrain research
Volume474
Issue number1
DOIs
StatePublished - Nov 22 1988
Externally publishedYes

Keywords

  • Cholecystokinin
  • Nervus vagus
  • Nodose ganglion
  • Nucleus tractus solitarii
  • Receptor
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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