Reduction of Biliverdin-C14 to Bilirubin-C14 in vivo

Gary W. Goldstein; Roger Lester

doi:10.3181/00379727-117-29666

Reduction of Biliverdin-C¹⁴ to Bilirubin-C¹⁴ in vivo

Research output: Contribution to journal › Article › peer-review

Abstract

Radiochemically pure biliverdin-C¹⁴ was administered intravenously to rats prepared with an external biliary fistula. A major fraction of the pigment was rapidly reduced to bilirubin and was recovered from the bile as conjugated bilirubin-C¹⁴. The results are consistent with the view that bili-verdin may be an intermediate in the degradation of hemoglobin to bilirubin.

Original language	English (US)
Pages (from-to)	681-683
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	117
Issue number	3
DOIs	https://doi.org/10.3181/00379727-117-29666
State	Published - Dec 1964
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.3181/00379727-117-29666

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title = "Reduction of Biliverdin-C14 to Bilirubin-C14 in vivo",

abstract = "Radiochemically pure biliverdin-C14 was administered intravenously to rats prepared with an external biliary fistula. A major fraction of the pigment was rapidly reduced to bilirubin and was recovered from the bile as conjugated bilirubin-C14. The results are consistent with the view that bili-verdin may be an intermediate in the degradation of hemoglobin to bilirubin.",

author = "Goldstein, {Gary W.} and Roger Lester",

note = "Funding Information: This work was supported in part by U.S.P.H.S. Grant AM-07091. 12 1964 117 3 681 683 ",

year = "1964",

month = dec,

doi = "10.3181/00379727-117-29666",

language = "English (US)",

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AU - Goldstein, Gary W.

AU - Lester, Roger

N1 - Funding Information: This work was supported in part by U.S.P.H.S. Grant AM-07091. 12 1964 117 3 681 683

PY - 1964/12

Y1 - 1964/12

N2 - Radiochemically pure biliverdin-C14 was administered intravenously to rats prepared with an external biliary fistula. A major fraction of the pigment was rapidly reduced to bilirubin and was recovered from the bile as conjugated bilirubin-C14. The results are consistent with the view that bili-verdin may be an intermediate in the degradation of hemoglobin to bilirubin.

AB - Radiochemically pure biliverdin-C14 was administered intravenously to rats prepared with an external biliary fistula. A major fraction of the pigment was rapidly reduced to bilirubin and was recovered from the bile as conjugated bilirubin-C14. The results are consistent with the view that bili-verdin may be an intermediate in the degradation of hemoglobin to bilirubin.

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Reduction of Biliverdin-C¹⁴ to Bilirubin-C¹⁴ in vivo

Abstract

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