Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children

David M. Stoff, Leafy Pollock, Benedetto Vitiello, David Behar, Wagner H. Bridger

Research output: Contribution to journalArticle

Abstract

Binding characteristics of tritiated imipramine on blood platelets were determined in daytime hospitalized prepubertal children who had mixed diagnoses of conduct disorder (CD) plus attention deficit disorder hyperactivity (ADDH) and in inpatient adolescents who had a history of aggressive behavior. The number of (3H)-imipramine maximal binding sites (Bmax) was significantly lower in the prepubertal patient group of CD plus ADDH; the dissociation constant (Kd) was not significantly different. There were significant negative correlations between Bmax and the Externalizing or Aggressive factors of the Child Behavior Checklist when the CD plus ADDH prepubertal patients were combined with their matched controls and within the adolescent inpatient group. We propose that a decreased platelet imipramine binding Bmaxvalue, as an index of disturbed presynaptic serotonergic activity, is not specific to depression and may be used as a biologic marker for the lack of behavioral constraint in heterogeneous populations of psychiatric patients.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalNeuropsychopharmacology
Volume1
Issue number1
StatePublished - Dec 1987
Externally publishedYes

Fingerprint

Conduct Disorder
Imipramine
Attention Deficit Disorder with Hyperactivity
Blood Platelets
Binding Sites
Inpatients
Dissociative Disorders
Hospitalized Child
Child Behavior
Checklist
Psychiatry
Biomarkers
Depression
Population

Keywords

  • (H)-imipramine binding
  • Aggression
  • Conduct disorder
  • Impulsivity
  • Platelets
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Stoff, D. M., Pollock, L., Vitiello, B., Behar, D., & Bridger, W. H. (1987). Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children. Neuropsychopharmacology, 1(1), 55-62.

Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children. / Stoff, David M.; Pollock, Leafy; Vitiello, Benedetto; Behar, David; Bridger, Wagner H.

In: Neuropsychopharmacology, Vol. 1, No. 1, 12.1987, p. 55-62.

Research output: Contribution to journalArticle

Stoff, DM, Pollock, L, Vitiello, B, Behar, D & Bridger, WH 1987, 'Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children', Neuropsychopharmacology, vol. 1, no. 1, pp. 55-62.
Stoff DM, Pollock L, Vitiello B, Behar D, Bridger WH. Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children. Neuropsychopharmacology. 1987 Dec;1(1):55-62.
Stoff, David M. ; Pollock, Leafy ; Vitiello, Benedetto ; Behar, David ; Bridger, Wagner H. / Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children. In: Neuropsychopharmacology. 1987 ; Vol. 1, No. 1. pp. 55-62.
@article{9954939e6b4e4ae4bb5df314f3822b3f,
title = "Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children",
abstract = "Binding characteristics of tritiated imipramine on blood platelets were determined in daytime hospitalized prepubertal children who had mixed diagnoses of conduct disorder (CD) plus attention deficit disorder hyperactivity (ADDH) and in inpatient adolescents who had a history of aggressive behavior. The number of (3H)-imipramine maximal binding sites (Bmax) was significantly lower in the prepubertal patient group of CD plus ADDH; the dissociation constant (Kd) was not significantly different. There were significant negative correlations between Bmax and the Externalizing or Aggressive factors of the Child Behavior Checklist when the CD plus ADDH prepubertal patients were combined with their matched controls and within the adolescent inpatient group. We propose that a decreased platelet imipramine binding Bmaxvalue, as an index of disturbed presynaptic serotonergic activity, is not specific to depression and may be used as a biologic marker for the lack of behavioral constraint in heterogeneous populations of psychiatric patients.",
keywords = "(H)-imipramine binding, Aggression, Conduct disorder, Impulsivity, Platelets, Serotonin",
author = "Stoff, {David M.} and Leafy Pollock and Benedetto Vitiello and David Behar and Bridger, {Wagner H.}",
year = "1987",
month = "12",
language = "English (US)",
volume = "1",
pages = "55--62",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children

AU - Stoff, David M.

AU - Pollock, Leafy

AU - Vitiello, Benedetto

AU - Behar, David

AU - Bridger, Wagner H.

PY - 1987/12

Y1 - 1987/12

N2 - Binding characteristics of tritiated imipramine on blood platelets were determined in daytime hospitalized prepubertal children who had mixed diagnoses of conduct disorder (CD) plus attention deficit disorder hyperactivity (ADDH) and in inpatient adolescents who had a history of aggressive behavior. The number of (3H)-imipramine maximal binding sites (Bmax) was significantly lower in the prepubertal patient group of CD plus ADDH; the dissociation constant (Kd) was not significantly different. There were significant negative correlations between Bmax and the Externalizing or Aggressive factors of the Child Behavior Checklist when the CD plus ADDH prepubertal patients were combined with their matched controls and within the adolescent inpatient group. We propose that a decreased platelet imipramine binding Bmaxvalue, as an index of disturbed presynaptic serotonergic activity, is not specific to depression and may be used as a biologic marker for the lack of behavioral constraint in heterogeneous populations of psychiatric patients.

AB - Binding characteristics of tritiated imipramine on blood platelets were determined in daytime hospitalized prepubertal children who had mixed diagnoses of conduct disorder (CD) plus attention deficit disorder hyperactivity (ADDH) and in inpatient adolescents who had a history of aggressive behavior. The number of (3H)-imipramine maximal binding sites (Bmax) was significantly lower in the prepubertal patient group of CD plus ADDH; the dissociation constant (Kd) was not significantly different. There were significant negative correlations between Bmax and the Externalizing or Aggressive factors of the Child Behavior Checklist when the CD plus ADDH prepubertal patients were combined with their matched controls and within the adolescent inpatient group. We propose that a decreased platelet imipramine binding Bmaxvalue, as an index of disturbed presynaptic serotonergic activity, is not specific to depression and may be used as a biologic marker for the lack of behavioral constraint in heterogeneous populations of psychiatric patients.

KW - (H)-imipramine binding

KW - Aggression

KW - Conduct disorder

KW - Impulsivity

KW - Platelets

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0023526286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023526286&partnerID=8YFLogxK

M3 - Article

C2 - 2855302

AN - SCOPUS:0023526286

VL - 1

SP - 55

EP - 62

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 1

ER -