Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial

Mark Espeland, Xavier Pi-Sunyer, George Blackburn, Frederick L. Brancati, George A. Bray, Renee Bright, Jeanne Clark, Jeffrey M. Curtis, John P. Foreyt, Kathryn Graves, Steven M. Haffner, Barbara Harrison, James O. Hill, Edward S. Horton, John Jakicic, Robert W. Jeffery, Karen C. Johnson, Steven Kahn, David E. Kelley, Abbas E. KitabchiWilliam C. Knowler, Cora E. Lewis, Barbara J. Maschak-Carey, Brenda Montgomery, David M. Nathan, Jennifer Patricio, Anne Peters, J. Bruce Redmon, Rebecca S. Reeves, Donna H. Ryan, Monika Safford, Brent Van Dorsten, Thomas A. Wadden, Lynne Wagenknecht, Jacqueline Wesche-Thobaben, Rena R. Wing, Susan Z. Yanovski

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events. RESEARCH DESIGN AND METHODS - This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45-74 years, with BMI >25 kg/m2 (>27 kg/m 2 if taking insulin). An intensive lifestyle intervention (ILI) involving group and individual meetings to achieve and maintain weight loss through decreased caloric intake and increased physical activity was compared with a diabetes support and education (DSE) condition. RESULTS - Participants assigned to ILI lost an average 8.6% of their initial weight vs. 0.7% in DSE group (P <0.001). Mean fitness increased in ILI by 20.9 vs. 5.8% in DSE (P <0.001). A greater proportion of ILI participants had reductions in diabetes, hypertension, and lipid-lowering medicines. Mean A1C dropped from 7.3 to 6.6% in ILI (P <0.001) vs. from 7.3 to 7.2% in DSE. Systolic and diastolic pressure, triglycerides, HDL cholesterol, and urine albumin-to-creatinine ratio improved significantly more in ILI than DSE participants (all P <0.01). CONCLUSIONS - At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes. This was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE. Continued intervention and follow-up will determine whether these changes are maintained and will reduce CVD risk.

Original languageEnglish (US)
Pages (from-to)1374-1383
Number of pages10
JournalDiabetes Care
Volume30
Issue number6
DOIs
StatePublished - May 2007

Fingerprint

Type 2 Diabetes Mellitus
Life Style
Weight Loss
Cardiovascular Diseases
Education
Blood Pressure
Group Processes
Energy Intake
HDL Cholesterol
Albumins
Creatinine
Triglycerides
Research Design
Randomized Controlled Trials
Medicine
Urine
Insulin
Hypertension
Lipids
Weights and Measures

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Espeland, M., Pi-Sunyer, X., Blackburn, G., Brancati, F. L., Bray, G. A., Bright, R., ... Yanovski, S. Z. (2007). Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial. Diabetes Care, 30(6), 1374-1383. https://doi.org/10.2337/dc07-0048

Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial. / Espeland, Mark; Pi-Sunyer, Xavier; Blackburn, George; Brancati, Frederick L.; Bray, George A.; Bright, Renee; Clark, Jeanne; Curtis, Jeffrey M.; Foreyt, John P.; Graves, Kathryn; Haffner, Steven M.; Harrison, Barbara; Hill, James O.; Horton, Edward S.; Jakicic, John; Jeffery, Robert W.; Johnson, Karen C.; Kahn, Steven; Kelley, David E.; Kitabchi, Abbas E.; Knowler, William C.; Lewis, Cora E.; Maschak-Carey, Barbara J.; Montgomery, Brenda; Nathan, David M.; Patricio, Jennifer; Peters, Anne; Redmon, J. Bruce; Reeves, Rebecca S.; Ryan, Donna H.; Safford, Monika; Van Dorsten, Brent; Wadden, Thomas A.; Wagenknecht, Lynne; Wesche-Thobaben, Jacqueline; Wing, Rena R.; Yanovski, Susan Z.

In: Diabetes Care, Vol. 30, No. 6, 05.2007, p. 1374-1383.

Research output: Contribution to journalArticle

Espeland, M, Pi-Sunyer, X, Blackburn, G, Brancati, FL, Bray, GA, Bright, R, Clark, J, Curtis, JM, Foreyt, JP, Graves, K, Haffner, SM, Harrison, B, Hill, JO, Horton, ES, Jakicic, J, Jeffery, RW, Johnson, KC, Kahn, S, Kelley, DE, Kitabchi, AE, Knowler, WC, Lewis, CE, Maschak-Carey, BJ, Montgomery, B, Nathan, DM, Patricio, J, Peters, A, Redmon, JB, Reeves, RS, Ryan, DH, Safford, M, Van Dorsten, B, Wadden, TA, Wagenknecht, L, Wesche-Thobaben, J, Wing, RR & Yanovski, SZ 2007, 'Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial', Diabetes Care, vol. 30, no. 6, pp. 1374-1383. https://doi.org/10.2337/dc07-0048
Espeland, Mark ; Pi-Sunyer, Xavier ; Blackburn, George ; Brancati, Frederick L. ; Bray, George A. ; Bright, Renee ; Clark, Jeanne ; Curtis, Jeffrey M. ; Foreyt, John P. ; Graves, Kathryn ; Haffner, Steven M. ; Harrison, Barbara ; Hill, James O. ; Horton, Edward S. ; Jakicic, John ; Jeffery, Robert W. ; Johnson, Karen C. ; Kahn, Steven ; Kelley, David E. ; Kitabchi, Abbas E. ; Knowler, William C. ; Lewis, Cora E. ; Maschak-Carey, Barbara J. ; Montgomery, Brenda ; Nathan, David M. ; Patricio, Jennifer ; Peters, Anne ; Redmon, J. Bruce ; Reeves, Rebecca S. ; Ryan, Donna H. ; Safford, Monika ; Van Dorsten, Brent ; Wadden, Thomas A. ; Wagenknecht, Lynne ; Wesche-Thobaben, Jacqueline ; Wing, Rena R. ; Yanovski, Susan Z. / Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial. In: Diabetes Care. 2007 ; Vol. 30, No. 6. pp. 1374-1383.
@article{c052308c58cb45dc8999cc98d84baf5c,
title = "Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial",
abstract = "OBJECTIVE - The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events. RESEARCH DESIGN AND METHODS - This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45-74 years, with BMI >25 kg/m2 (>27 kg/m 2 if taking insulin). An intensive lifestyle intervention (ILI) involving group and individual meetings to achieve and maintain weight loss through decreased caloric intake and increased physical activity was compared with a diabetes support and education (DSE) condition. RESULTS - Participants assigned to ILI lost an average 8.6{\%} of their initial weight vs. 0.7{\%} in DSE group (P <0.001). Mean fitness increased in ILI by 20.9 vs. 5.8{\%} in DSE (P <0.001). A greater proportion of ILI participants had reductions in diabetes, hypertension, and lipid-lowering medicines. Mean A1C dropped from 7.3 to 6.6{\%} in ILI (P <0.001) vs. from 7.3 to 7.2{\%} in DSE. Systolic and diastolic pressure, triglycerides, HDL cholesterol, and urine albumin-to-creatinine ratio improved significantly more in ILI than DSE participants (all P <0.01). CONCLUSIONS - At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes. This was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE. Continued intervention and follow-up will determine whether these changes are maintained and will reduce CVD risk.",
author = "Mark Espeland and Xavier Pi-Sunyer and George Blackburn and Brancati, {Frederick L.} and Bray, {George A.} and Renee Bright and Jeanne Clark and Curtis, {Jeffrey M.} and Foreyt, {John P.} and Kathryn Graves and Haffner, {Steven M.} and Barbara Harrison and Hill, {James O.} and Horton, {Edward S.} and John Jakicic and Jeffery, {Robert W.} and Johnson, {Karen C.} and Steven Kahn and Kelley, {David E.} and Kitabchi, {Abbas E.} and Knowler, {William C.} and Lewis, {Cora E.} and Maschak-Carey, {Barbara J.} and Brenda Montgomery and Nathan, {David M.} and Jennifer Patricio and Anne Peters and Redmon, {J. Bruce} and Reeves, {Rebecca S.} and Ryan, {Donna H.} and Monika Safford and {Van Dorsten}, Brent and Wadden, {Thomas A.} and Lynne Wagenknecht and Jacqueline Wesche-Thobaben and Wing, {Rena R.} and Yanovski, {Susan Z.}",
year = "2007",
month = "5",
doi = "10.2337/dc07-0048",
language = "English (US)",
volume = "30",
pages = "1374--1383",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "6",

}

TY - JOUR

T1 - Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial

AU - Espeland, Mark

AU - Pi-Sunyer, Xavier

AU - Blackburn, George

AU - Brancati, Frederick L.

AU - Bray, George A.

AU - Bright, Renee

AU - Clark, Jeanne

AU - Curtis, Jeffrey M.

AU - Foreyt, John P.

AU - Graves, Kathryn

AU - Haffner, Steven M.

AU - Harrison, Barbara

AU - Hill, James O.

AU - Horton, Edward S.

AU - Jakicic, John

AU - Jeffery, Robert W.

AU - Johnson, Karen C.

AU - Kahn, Steven

AU - Kelley, David E.

AU - Kitabchi, Abbas E.

AU - Knowler, William C.

AU - Lewis, Cora E.

AU - Maschak-Carey, Barbara J.

AU - Montgomery, Brenda

AU - Nathan, David M.

AU - Patricio, Jennifer

AU - Peters, Anne

AU - Redmon, J. Bruce

AU - Reeves, Rebecca S.

AU - Ryan, Donna H.

AU - Safford, Monika

AU - Van Dorsten, Brent

AU - Wadden, Thomas A.

AU - Wagenknecht, Lynne

AU - Wesche-Thobaben, Jacqueline

AU - Wing, Rena R.

AU - Yanovski, Susan Z.

PY - 2007/5

Y1 - 2007/5

N2 - OBJECTIVE - The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events. RESEARCH DESIGN AND METHODS - This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45-74 years, with BMI >25 kg/m2 (>27 kg/m 2 if taking insulin). An intensive lifestyle intervention (ILI) involving group and individual meetings to achieve and maintain weight loss through decreased caloric intake and increased physical activity was compared with a diabetes support and education (DSE) condition. RESULTS - Participants assigned to ILI lost an average 8.6% of their initial weight vs. 0.7% in DSE group (P <0.001). Mean fitness increased in ILI by 20.9 vs. 5.8% in DSE (P <0.001). A greater proportion of ILI participants had reductions in diabetes, hypertension, and lipid-lowering medicines. Mean A1C dropped from 7.3 to 6.6% in ILI (P <0.001) vs. from 7.3 to 7.2% in DSE. Systolic and diastolic pressure, triglycerides, HDL cholesterol, and urine albumin-to-creatinine ratio improved significantly more in ILI than DSE participants (all P <0.01). CONCLUSIONS - At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes. This was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE. Continued intervention and follow-up will determine whether these changes are maintained and will reduce CVD risk.

AB - OBJECTIVE - The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events. RESEARCH DESIGN AND METHODS - This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45-74 years, with BMI >25 kg/m2 (>27 kg/m 2 if taking insulin). An intensive lifestyle intervention (ILI) involving group and individual meetings to achieve and maintain weight loss through decreased caloric intake and increased physical activity was compared with a diabetes support and education (DSE) condition. RESULTS - Participants assigned to ILI lost an average 8.6% of their initial weight vs. 0.7% in DSE group (P <0.001). Mean fitness increased in ILI by 20.9 vs. 5.8% in DSE (P <0.001). A greater proportion of ILI participants had reductions in diabetes, hypertension, and lipid-lowering medicines. Mean A1C dropped from 7.3 to 6.6% in ILI (P <0.001) vs. from 7.3 to 7.2% in DSE. Systolic and diastolic pressure, triglycerides, HDL cholesterol, and urine albumin-to-creatinine ratio improved significantly more in ILI than DSE participants (all P <0.01). CONCLUSIONS - At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes. This was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE. Continued intervention and follow-up will determine whether these changes are maintained and will reduce CVD risk.

UR - http://www.scopus.com/inward/record.url?scp=34249864128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249864128&partnerID=8YFLogxK

U2 - 10.2337/dc07-0048

DO - 10.2337/dc07-0048

M3 - Article

C2 - 17363746

AN - SCOPUS:34249864128

VL - 30

SP - 1374

EP - 1383

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 6

ER -