Reduction in number of immunostained GABAergic neurones in deprived-eye dominance columns of monkey area 17

Stewart H Hendry, E. G. Jones

Research output: Contribution to journalArticle

Abstract

The primary visual cortex (area 17) of the Old World monkey is divided into alternating right- and left-eye dominance columns1-3 that are highly modifiable by visual experience during a critical period in development but display little morphological or physiological plasticity during adult life 4,5. However, changes in immunocytochemical staining for a calcium/calmodulin-dependent protein kinase occur in visual cortical neurones of adult monkeys after brief monocular deprivation6 and concentrations of putative neurotransmitters or their related enzymes can be altered with changes in neuronal activity in other systems7-9. We therefore examined the effects of monocular deprivation on the immunocytochemical staining for γ-aminobutyric acid (GABA) and its synthetic enzyme, glutamic acid decarboxylase (GAD), in adult monkey area 17. The staining for GABA and GAD in neuronal somata and terminals was markedly reduced within ocular dominance columns associated with a removed or a visually deprived eye, suggesting that the GABA concentration in cortical neurones may depend on their levels of activity. Thus area 17 of adult monkeys may retain a greater degree of plasticity than previously recognized and sensory experience can profoundly affect transmitter levels, in the cortex, apparently by regulating levels of a synthetic enzyme.

Original languageEnglish (US)
Pages (from-to)750-753
Number of pages4
JournalNature
Volume320
Issue number6064
DOIs
StatePublished - 1986
Externally publishedYes

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ocular Dominance
GABAergic Neurons
gamma-Aminobutyric Acid
Haplorhini
Glutamate Decarboxylase
Staining and Labeling
Enzymes
Cercopithecidae
Aminobutyrates
Neurons
Calcium-Calmodulin-Dependent Protein Kinases
Carisoprodol
Visual Cortex
Neurotransmitter Agents

ASJC Scopus subject areas

  • General

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Reduction in number of immunostained GABAergic neurones in deprived-eye dominance columns of monkey area 17. / Hendry, Stewart H; Jones, E. G.

In: Nature, Vol. 320, No. 6064, 1986, p. 750-753.

Research output: Contribution to journalArticle

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