Reducing variability in anatomical definitions over time using longitudinal diffeomorphic mapping

Daniel J. Tward, Chelsea S. Sicat, Timothy Brown, Arnold Bakker, Michael I. Miller

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We address the challenge of variability in the definition of anatomical structures over time in a single subject, using a templatebased diffeomorphic mapping algorithm to filter out inconsistencies. Shape changes are parametrized through 2D surfaces, while data attachment is specified through dense 3D images. The mapping uses two geodesic trajectories through diffeomorphism space: template to baseline, and baseline through the timeseries. We apply this algorithm to a study of atrophy in the entorhinal and surrounding cortex in patients with mild cognitive impairment, characterized by rate of change of log-volume. We compare the uncertainty in atrophy rate measured from manual segmentations, to that computed with segmentations filtered using our longitudinal method, and to that computed from FreeSurfer. Our method correlates well with manual (correlation coefficient 0.9881, and results in significantly less variability than manual (p 8.86e-05) and FreeSurfer (p 1.03e-04).

Original languageEnglish (US)
Title of host publicationSpectral and Shape Analysis in Medical Imaging - First International Workshop, SeSAMI 2016 Held in Conjunction with MICCAI 2016, Revised Selected Papers
PublisherSpringer Verlag
Pages51-62
Number of pages12
Volume10126 LNCS
ISBN (Print)9783319512365
DOIs
StatePublished - 2016
Event1st International Workshop on Spectral and Shape Analysis in Medical Imaging, SeSAMI 2016 Held in Conjunction with 19th International Conference on Medical Image Computing and Computer Assisted Interventions, MICCAI 2016 - Athens, Greece
Duration: Oct 21 2016Oct 21 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10126 LNCS
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other1st International Workshop on Spectral and Shape Analysis in Medical Imaging, SeSAMI 2016 Held in Conjunction with 19th International Conference on Medical Image Computing and Computer Assisted Interventions, MICCAI 2016
CountryGreece
CityAthens
Period10/21/1610/21/16

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Tward, D. J., Sicat, C. S., Brown, T., Bakker, A., & Miller, M. I. (2016). Reducing variability in anatomical definitions over time using longitudinal diffeomorphic mapping. In Spectral and Shape Analysis in Medical Imaging - First International Workshop, SeSAMI 2016 Held in Conjunction with MICCAI 2016, Revised Selected Papers (Vol. 10126 LNCS, pp. 51-62). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10126 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-51237-2_5