TY - JOUR
T1 - Reducing the risk of mother-to-child human immunodeficiency virus transmission
T2 - past successes, current progress and challenges, and future directions
AU - Fowler, Mary Glenn
AU - Lampe, Margaret A.
AU - Jamieson, Denise J.
AU - Kourtis, Athena P.
AU - Rogers, Martha F.
PY - 2007/9
Y1 - 2007/9
N2 - Prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) in the United States and Europe has been a tremendous success, such that transmission rates of less than 2% have been achieved. Some key successes have also been demonstrated in resource-poor countries; however, the translation of successful interventions into public health policy has been slow because of a variety of factors such as inadequate funding and cultural, social, and institutional barriers. The issue of HIV and infant feeding in settings that lack culturally acceptable, feasible, affordable, safe, and sustainable nutritional substitutes for breast milk is a continuing dilemma. An effective preventive infant HIV vaccine would be an optimal approach to reduce HIV acquisition in the first year of life among breast-feeding infants. The challenges to eliminate new perinatal HIV infections worldwide will depend on both sustaining and expanding PMTCT interventions and effective primary HIV prevention for women, adolescents, and young adults.
AB - Prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) in the United States and Europe has been a tremendous success, such that transmission rates of less than 2% have been achieved. Some key successes have also been demonstrated in resource-poor countries; however, the translation of successful interventions into public health policy has been slow because of a variety of factors such as inadequate funding and cultural, social, and institutional barriers. The issue of HIV and infant feeding in settings that lack culturally acceptable, feasible, affordable, safe, and sustainable nutritional substitutes for breast milk is a continuing dilemma. An effective preventive infant HIV vaccine would be an optimal approach to reduce HIV acquisition in the first year of life among breast-feeding infants. The challenges to eliminate new perinatal HIV infections worldwide will depend on both sustaining and expanding PMTCT interventions and effective primary HIV prevention for women, adolescents, and young adults.
KW - acquired immunodeficiency syndrome
KW - human immunodeficiency virus
KW - mother-to-child transmission
KW - pregnancy
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U2 - 10.1016/j.ajog.2007.06.048
DO - 10.1016/j.ajog.2007.06.048
M3 - Review article
C2 - 17825648
AN - SCOPUS:34548394670
SN - 0002-9378
VL - 197
SP - S3-S9
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3 SUPPL.
ER -