Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord

Gaby J. Ritfeld; Rishi D. Nandoe Tewarie; Sahar T. Rahiem; Andres Hurtado; Raymund A. Roos; Andre Grotenhuis; Martin Oudega

doi:10.1097/WNR.0b013e32833677cd

Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord

Gaby J. Ritfeld, Rishi D. Nandoe Tewarie, Sahar T. Rahiem, Andres Hurtado, Raymund A. Roos, Andre Grotenhuis, Martin Oudega

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point, survival 7 days later was similar between treatment groups and saline-injected controls. In fact, we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion.

Original language	English (US)
Pages (from-to)	221-226
Number of pages	6
Journal	Neuroreport
Volume	21
Issue number	3
DOIs	https://doi.org/10.1097/WNR.0b013e32833677cd
State	Published - Feb 2010
Externally published	Yes

Keywords

Bone marrow stromal cell
Cell survival
Cell transplantation
Macrophages
Spinal cord injury
Trauma

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/WNR.0b013e32833677cd

Cite this

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title = "Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord",

abstract = "We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point, survival 7 days later was similar between treatment groups and saline-injected controls. In fact, we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion.",

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AU - Ritfeld, Gaby J.

AU - Nandoe Tewarie, Rishi D.

AU - Rahiem, Sahar T.

AU - Hurtado, Andres

AU - Roos, Raymund A.

AU - Grotenhuis, Andre

AU - Oudega, Martin

PY - 2010/2

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AB - We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point, survival 7 days later was similar between treatment groups and saline-injected controls. In fact, we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion.

KW - Bone marrow stromal cell

KW - Cell survival

KW - Cell transplantation

KW - Macrophages

KW - Spinal cord injury

KW - Trauma

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Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord

Abstract

Keywords

ASJC Scopus subject areas

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