Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord

Gaby J. Ritfeld, Rishi D. Nandoe Tewarie, Sahar T. Rahiem, Andres Hurtado, Raymund A. Roos, Andre Grotenhuis, Martin Oudega

Research output: Contribution to journalArticle

Abstract

We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point, survival 7 days later was similar between treatment groups and saline-injected controls. In fact, we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalNeuroReport
Volume21
Issue number3
DOIs
StatePublished - Feb 2010

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Contusions
Mesenchymal Stromal Cells
Cell Survival
Spinal Cord
Macrophages
Minocycline
Methylprednisolone
Cyclosporine
Thorax

Keywords

  • Bone marrow stromal cell
  • Cell survival
  • Cell transplantation
  • Macrophages
  • Spinal cord injury
  • Trauma

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ritfeld, G. J., Nandoe Tewarie, R. D., Rahiem, S. T., Hurtado, A., Roos, R. A., Grotenhuis, A., & Oudega, M. (2010). Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. NeuroReport, 21(3), 221-226. https://doi.org/10.1097/WNR.0b013e32833677cd

Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. / Ritfeld, Gaby J.; Nandoe Tewarie, Rishi D.; Rahiem, Sahar T.; Hurtado, Andres; Roos, Raymund A.; Grotenhuis, Andre; Oudega, Martin.

In: NeuroReport, Vol. 21, No. 3, 02.2010, p. 221-226.

Research output: Contribution to journalArticle

Ritfeld, GJ, Nandoe Tewarie, RD, Rahiem, ST, Hurtado, A, Roos, RA, Grotenhuis, A & Oudega, M 2010, 'Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord', NeuroReport, vol. 21, no. 3, pp. 221-226. https://doi.org/10.1097/WNR.0b013e32833677cd
Ritfeld GJ, Nandoe Tewarie RD, Rahiem ST, Hurtado A, Roos RA, Grotenhuis A et al. Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. NeuroReport. 2010 Feb;21(3):221-226. https://doi.org/10.1097/WNR.0b013e32833677cd
Ritfeld, Gaby J. ; Nandoe Tewarie, Rishi D. ; Rahiem, Sahar T. ; Hurtado, Andres ; Roos, Raymund A. ; Grotenhuis, Andre ; Oudega, Martin. / Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. In: NeuroReport. 2010 ; Vol. 21, No. 3. pp. 221-226.
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