Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord

Gaby J. Ritfeld, Rishi D. Nandoe Tewarie, Sahar T. Rahiem, Andres Hurtado, Raymund A. Roos, Andre Grotenhuis, Martin Oudega

Research output: Contribution to journalArticle

Abstract

We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point, survival 7 days later was similar between treatment groups and saline-injected controls. In fact, we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalNeuroreport
Volume21
Issue number3
DOIs
StatePublished - Feb 1 2010

Keywords

  • Bone marrow stromal cell
  • Cell survival
  • Cell transplantation
  • Macrophages
  • Spinal cord injury
  • Trauma

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord'. Together they form a unique fingerprint.

  • Cite this

    Ritfeld, G. J., Nandoe Tewarie, R. D., Rahiem, S. T., Hurtado, A., Roos, R. A., Grotenhuis, A., & Oudega, M. (2010). Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. Neuroreport, 21(3), 221-226. https://doi.org/10.1097/WNR.0b013e32833677cd