Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis

Increased iron content?

B. Drayer, P. Burger, B. Hurwitz, D. Dawson, J. Cain

Research output: Contribution to journalArticle

Abstract

High-field-strength (1.5-T) MR imaging was used to evaluate 47 patients with definite multiple sclerosis and 42 neurologically normal control patients. Abnormal, multiple foci of increased signal intensity on T2-weighted images, most prominent in the periventricular white matter, were apparent in 43 of 47 MS patients and in two of 42 control patients. A previously undescribed finding of relatively decreased signal intensity most evident in the putamen and thalamus on T2-weighted images was seen in 25 of 42 MS patients and correlated with the degree of white-matter abnormality. In the normal control patients a prominently decreased signal intensity was noted in the globus pallidus, as compared with the putamen or thalamus, correlating closely with the distribution of ferric iron as determined in normal Perls'-stained autopsy brains. The decreased signal intensity (decreased T2) is due to ferritin, which causes local magnetic field inhomogeneities and is proportional to the square of the field strength. The decreased T2 in the thalamus and striatum in MS may be related to abnormally increased iron accumulation in these locales with the underlying mechanism remaining speculative.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalAmerican Journal of Roentgenology
Volume149
Issue number2
StatePublished - 1987
Externally publishedYes

Fingerprint

Putamen
Thalamus
Multiple Sclerosis
Iron
Globus Pallidus
Magnetic Fields
Ferritins
Autopsy
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis : Increased iron content? / Drayer, B.; Burger, P.; Hurwitz, B.; Dawson, D.; Cain, J.

In: American Journal of Roentgenology, Vol. 149, No. 2, 1987, p. 357-363.

Research output: Contribution to journalArticle

Drayer, B, Burger, P, Hurwitz, B, Dawson, D & Cain, J 1987, 'Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: Increased iron content?', American Journal of Roentgenology, vol. 149, no. 2, pp. 357-363.
Drayer, B. ; Burger, P. ; Hurwitz, B. ; Dawson, D. ; Cain, J. / Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis : Increased iron content?. In: American Journal of Roentgenology. 1987 ; Vol. 149, No. 2. pp. 357-363.
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