Reduced risk of pancreatic cancer associated with asthma and nasal allergies

Paulina Gomez-Rubio, Jan Paul Zock, Marta Rava, Mirari Marquez, Linda Sharp, Manuel Hidalgo, Alfredo Carrato, Lucas Ilzarbe, Christoph Michalski, Xavier Molero, Antoni Farré, José Perea, William Greenhalf, Michael O'Rorke, Adonina Tardón, Thomas Gress, Victor Barberà, Tatjana Crnogorac-Jurcevic, Enrique Domínguez-Munõz, Luís Munõz-BellvísCristina Alvarez-Urturi, Joaquim Balcells, Luis Barneo, Eithne Costello, Carmen Guillén-Ponce, Jörg Kleeff, Bo Kong, Rita Lawlor, Matthias Löhr, Josefina Mora, Lim Murray, Damian O'Driscoll, Pablo Pelaéz, Ignasi Poves, Aldo Scarpa, Francisco X. Real, Núria Malats

Research output: Contribution to journalArticle

Abstract

Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Metaanalyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly longstanding asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.

Original languageEnglish (US)
Pages (from-to)314-322
Number of pages9
JournalGut
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Reduced risk of pancreatic cancer associated with asthma and nasal allergies'. Together they form a unique fingerprint.

  • Cite this

    Gomez-Rubio, P., Zock, J. P., Rava, M., Marquez, M., Sharp, L., Hidalgo, M., Carrato, A., Ilzarbe, L., Michalski, C., Molero, X., Farré, A., Perea, J., Greenhalf, W., O'Rorke, M., Tardón, A., Gress, T., Barberà, V., Crnogorac-Jurcevic, T., Domínguez-Munõz, E., ... Malats, N. (2017). Reduced risk of pancreatic cancer associated with asthma and nasal allergies. Gut, 66(2), 314-322. https://doi.org/10.1136/gutjnl-2015-310442