TY - JOUR
T1 - Reduced risk of pancreatic cancer associated with asthma and nasal allergies
AU - Gomez-Rubio, Paulina
AU - Zock, Jan Paul
AU - Rava, Marta
AU - Marquez, Mirari
AU - Sharp, Linda
AU - Hidalgo, Manuel
AU - Carrato, Alfredo
AU - Ilzarbe, Lucas
AU - Michalski, Christoph
AU - Molero, Xavier
AU - Farré, Antoni
AU - Perea, José
AU - Greenhalf, William
AU - O'Rorke, Michael
AU - Tardón, Adonina
AU - Gress, Thomas
AU - Barberà, Victor
AU - Crnogorac-Jurcevic, Tatjana
AU - Domínguez-Munõz, Enrique
AU - Munõz-Bellvís, Luís
AU - Alvarez-Urturi, Cristina
AU - Balcells, Joaquim
AU - Barneo, Luis
AU - Costello, Eithne
AU - Guillén-Ponce, Carmen
AU - Kleeff, Jörg
AU - Kong, Bo
AU - Lawlor, Rita
AU - Löhr, Matthias
AU - Mora, Josefina
AU - Murray, Lim
AU - O'Driscoll, Damian
AU - Pelaéz, Pablo
AU - Poves, Ignasi
AU - Scarpa, Aldo
AU - Real, Francisco X.
AU - Malats, Núria
N1 - Funding Information:
The work was partially supported by Fondo de Investigaciones Sanitarias (FIS), Instituto de Salud Carlos III, Spain (#PI11/01542, #PI0902102, #PI12/01635, #PI12/00815); Red Temática de Investigación Cooperativa en Cáncer, Spain (#RD12/0036/0034, #RD12/0036/0050, #RD12/0036/0073); European Cooperation in Science and Technology-COST Action #BM1204: EUPancreas. Acción Especial de Genómica, Spain (#GEN2001-4748-c05-03); EU-6FP Integrated Project (#018771-MOLDIAG-PACA), EU-FP7-HEALTH (#259737-CANCERALIA, #256974-EPC-TM-Net), Cancer Focus Northern Ireland and Department for Employment and Learning; and ALF (#SLL20130022), Sweden.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Metaanalyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly longstanding asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.
AB - Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Metaanalyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly longstanding asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.
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U2 - 10.1136/gutjnl-2015-310442
DO - 10.1136/gutjnl-2015-310442
M3 - Article
C2 - 26628509
AN - SCOPUS:84954287569
SN - 0017-5749
VL - 66
SP - 314
EP - 322
JO - Gut
JF - Gut
IS - 2
ER -