Reduced risk of pancreatic cancer associated with asthma and nasal allergies

Paulina Gomez-Rubio, Jan Paul Zock, Marta Rava, Mirari Marquez, Linda Sharp, Manuel Hidalgo, Alfredo Carrato, Lucas Ilzarbe, Christoph Michalski, Xavier Molero, Antoni Farré, José Perea, William Greenhalf, Michael O'Rorke, Adonina Tardón, Thomas Gress, Victor Barberà, Tatjana Crnogorac-Jurcevic, Enrique Domínguez-Muñoz, Luís Muñoz-Bellvís & 17 others Cristina Alvarez-Urturi, Joaquim Balcells, Luis Barneo, Eithne Costello, Carmen Guillén-Ponce, Jörg Kleeff, Bo Kong, Rita Lawlor, Matthias Löhr, Josefina Mora, Lim Murray, Damian O'Driscoll, Pablo Peláez, Ignasi Poves, Aldo Scarpa, Francisco X. Real, Núria Malats

Research output: Contribution to journalArticle

Abstract

Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Metaanalyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly longstanding asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.

Original languageEnglish (US)
JournalGut
DOIs
StateAccepted/In press - Dec 1 2015
Externally publishedYes

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Pancreatic Neoplasms
Nose
Hypersensitivity
Asthma
Meta-Analysis
Case-Control Studies
Pancreas
Neoplasms
Carcinogenesis
Adenocarcinoma
Logistic Models
Regression Analysis
Skin
Research

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gomez-Rubio, P., Zock, J. P., Rava, M., Marquez, M., Sharp, L., Hidalgo, M., ... Malats, N. (Accepted/In press). Reduced risk of pancreatic cancer associated with asthma and nasal allergies. Gut. https://doi.org/10.1136/gutjnl-2015-310442

Reduced risk of pancreatic cancer associated with asthma and nasal allergies. / Gomez-Rubio, Paulina; Zock, Jan Paul; Rava, Marta; Marquez, Mirari; Sharp, Linda; Hidalgo, Manuel; Carrato, Alfredo; Ilzarbe, Lucas; Michalski, Christoph; Molero, Xavier; Farré, Antoni; Perea, José; Greenhalf, William; O'Rorke, Michael; Tardón, Adonina; Gress, Thomas; Barberà, Victor; Crnogorac-Jurcevic, Tatjana; Domínguez-Muñoz, Enrique; Muñoz-Bellvís, Luís; Alvarez-Urturi, Cristina; Balcells, Joaquim; Barneo, Luis; Costello, Eithne; Guillén-Ponce, Carmen; Kleeff, Jörg; Kong, Bo; Lawlor, Rita; Löhr, Matthias; Mora, Josefina; Murray, Lim; O'Driscoll, Damian; Peláez, Pablo; Poves, Ignasi; Scarpa, Aldo; Real, Francisco X.; Malats, Núria.

In: Gut, 01.12.2015.

Research output: Contribution to journalArticle

Gomez-Rubio, P, Zock, JP, Rava, M, Marquez, M, Sharp, L, Hidalgo, M, Carrato, A, Ilzarbe, L, Michalski, C, Molero, X, Farré, A, Perea, J, Greenhalf, W, O'Rorke, M, Tardón, A, Gress, T, Barberà, V, Crnogorac-Jurcevic, T, Domínguez-Muñoz, E, Muñoz-Bellvís, L, Alvarez-Urturi, C, Balcells, J, Barneo, L, Costello, E, Guillén-Ponce, C, Kleeff, J, Kong, B, Lawlor, R, Löhr, M, Mora, J, Murray, L, O'Driscoll, D, Peláez, P, Poves, I, Scarpa, A, Real, FX & Malats, N 2015, 'Reduced risk of pancreatic cancer associated with asthma and nasal allergies', Gut. https://doi.org/10.1136/gutjnl-2015-310442
Gomez-Rubio P, Zock JP, Rava M, Marquez M, Sharp L, Hidalgo M et al. Reduced risk of pancreatic cancer associated with asthma and nasal allergies. Gut. 2015 Dec 1. https://doi.org/10.1136/gutjnl-2015-310442
Gomez-Rubio, Paulina ; Zock, Jan Paul ; Rava, Marta ; Marquez, Mirari ; Sharp, Linda ; Hidalgo, Manuel ; Carrato, Alfredo ; Ilzarbe, Lucas ; Michalski, Christoph ; Molero, Xavier ; Farré, Antoni ; Perea, José ; Greenhalf, William ; O'Rorke, Michael ; Tardón, Adonina ; Gress, Thomas ; Barberà, Victor ; Crnogorac-Jurcevic, Tatjana ; Domínguez-Muñoz, Enrique ; Muñoz-Bellvís, Luís ; Alvarez-Urturi, Cristina ; Balcells, Joaquim ; Barneo, Luis ; Costello, Eithne ; Guillén-Ponce, Carmen ; Kleeff, Jörg ; Kong, Bo ; Lawlor, Rita ; Löhr, Matthias ; Mora, Josefina ; Murray, Lim ; O'Driscoll, Damian ; Peláez, Pablo ; Poves, Ignasi ; Scarpa, Aldo ; Real, Francisco X. ; Malats, Núria. / Reduced risk of pancreatic cancer associated with asthma and nasal allergies. In: Gut. 2015.
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title = "Reduced risk of pancreatic cancer associated with asthma and nasal allergies",
abstract = "Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Metaanalyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95{\%} CI 0.47 to 0.88), particularly longstanding asthma (>=17 years, OR 0.39, 95{\%} CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95{\%} CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95{\%} CI 0.52 to 0.83 and OR 0.59, 95{\%} CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95{\%} CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.",
author = "Paulina Gomez-Rubio and Zock, {Jan Paul} and Marta Rava and Mirari Marquez and Linda Sharp and Manuel Hidalgo and Alfredo Carrato and Lucas Ilzarbe and Christoph Michalski and Xavier Molero and Antoni Farr{\'e} and Jos{\'e} Perea and William Greenhalf and Michael O'Rorke and Adonina Tard{\'o}n and Thomas Gress and Victor Barber{\`a} and Tatjana Crnogorac-Jurcevic and Enrique Dom{\'i}nguez-Mu{\~n}oz and Lu{\'i}s Mu{\~n}oz-Bellv{\'i}s and Cristina Alvarez-Urturi and Joaquim Balcells and Luis Barneo and Eithne Costello and Carmen Guill{\'e}n-Ponce and J{\"o}rg Kleeff and Bo Kong and Rita Lawlor and Matthias L{\"o}hr and Josefina Mora and Lim Murray and Damian O'Driscoll and Pablo Pel{\'a}ez and Ignasi Poves and Aldo Scarpa and Real, {Francisco X.} and N{\'u}ria Malats",
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T1 - Reduced risk of pancreatic cancer associated with asthma and nasal allergies

AU - Gomez-Rubio, Paulina

AU - Zock, Jan Paul

AU - Rava, Marta

AU - Marquez, Mirari

AU - Sharp, Linda

AU - Hidalgo, Manuel

AU - Carrato, Alfredo

AU - Ilzarbe, Lucas

AU - Michalski, Christoph

AU - Molero, Xavier

AU - Farré, Antoni

AU - Perea, José

AU - Greenhalf, William

AU - O'Rorke, Michael

AU - Tardón, Adonina

AU - Gress, Thomas

AU - Barberà, Victor

AU - Crnogorac-Jurcevic, Tatjana

AU - Domínguez-Muñoz, Enrique

AU - Muñoz-Bellvís, Luís

AU - Alvarez-Urturi, Cristina

AU - Balcells, Joaquim

AU - Barneo, Luis

AU - Costello, Eithne

AU - Guillén-Ponce, Carmen

AU - Kleeff, Jörg

AU - Kong, Bo

AU - Lawlor, Rita

AU - Löhr, Matthias

AU - Mora, Josefina

AU - Murray, Lim

AU - O'Driscoll, Damian

AU - Peláez, Pablo

AU - Poves, Ignasi

AU - Scarpa, Aldo

AU - Real, Francisco X.

AU - Malats, Núria

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Metaanalyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly longstanding asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.

AB - Objective Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk. Design Information about asthma and allergies was collated from 1297 PDAC cases and 1024 controls included in the PanGenEU case-control study. Associations between PDAC and atopic diseases were studied using multilevel logistic regression analysis. Metaanalyses of association studies on these diseases and PDAC risk were performed applying random-effects model. Results Asthma was associated with lower risk of PDAC (OR 0.64, 95% CI 0.47 to 0.88), particularly longstanding asthma (>=17 years, OR 0.39, 95% CI 0.24 to 0.65). Meta-analysis of 10 case-control studies sustained our results (metaOR 0.73, 95% CI 0.59 to 0.89). Nasal allergies and related symptoms were associated with lower risk of PDAC (OR 0.66, 95% CI 0.52 to 0.83 and OR 0.59, 95% CI 0.46 to 0.77, respectively). These results were supported by a meta-analysis of nasal allergy studies (metaOR 0.6, 95% CI 0.5 to 0.72). Skin allergies were not associated with PDAC risk. Conclusions This study shows a consistent inverse association between PDAC and asthma and nasal allergies, supporting the notion that atopic diseases are associated with reduced cancer risk. These results point to the involvement of immune and/or inflammatory factors that may either foster or restrain pancreas carcinogenesis warranting further research to understand the molecular mechanisms driving this association.

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