Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Andreas Meyer-Lindenberg, Robert S. Miletich, Philip D. Kohn, Giuseppe Esposito, Richard E. Carson, Mario Quarantelli, Daniel R. Weinberger, Karen Faith Berman

Research output: Contribution to journalArticle

Abstract

Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant Ki in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalNature neuroscience
Volume5
Issue number3
DOIs
StatePublished - Mar 2002
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Meyer-Lindenberg, A., Miletich, R. S., Kohn, P. D., Esposito, G., Carson, R. E., Quarantelli, M., Weinberger, D. R., & Berman, K. F. (2002). Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nature neuroscience, 5(3), 267-271. https://doi.org/10.1038/nn804