Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Andreas Meyer-Lindenberg; Robert S. Miletich; Philip D. Kohn; Giuseppe Esposito; Richard E. Carson; Mario Quarantelli; Daniel R. Weinberger; Karen Faith Berman

doi:10.1038/nn804

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Andreas Meyer-Lindenberg, Robert S. Miletich, Philip D. Kohn, Giuseppe Esposito, Richard E. Carson, Mario Quarantelli, Daniel R. Weinberger, Karen Faith Berman

Research output: Contribution to journal › Article › peer-review

517 Scopus citations

Abstract

Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant K_i in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.

Original language	English (US)
Pages (from-to)	267-271
Number of pages	5
Journal	Nature neuroscience
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/nn804
State	Published - Mar 2002
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia",

abstract = "Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant Ki in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.",

author = "Andreas Meyer-Lindenberg and Miletich, {Robert S.} and Kohn, {Philip D.} and Giuseppe Esposito and Carson, {Richard E.} and Mario Quarantelli and Weinberger, {Daniel R.} and Berman, {Karen Faith}",

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T1 - Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

AU - Meyer-Lindenberg, Andreas

AU - Miletich, Robert S.

AU - Kohn, Philip D.

AU - Esposito, Giuseppe

AU - Carson, Richard E.

AU - Quarantelli, Mario

AU - Weinberger, Daniel R.

AU - Berman, Karen Faith

PY - 2002/3

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Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Abstract

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