Reduced olfactory bulb volume in patients with schizophrenia

Bruce I. Turetsky, Paul J. Moberg, David Mark Yousem, Richard L. Doty, Steven E. Arnold, Raquel E. Gur

Research output: Contribution to journalArticle

Abstract

Objective: The authors' goal in this study was to compare the size of olfactory bulbs of patients with schizophrenia and those of healthy subjects. Method: Magnetic resonance imaging scans of olfactory bulbs were obtained from 26 patients with schizophrenia and 22 healthy comparison subjects. A reliable region of interest procedure was used to measure olfactory bulb volume. Results: Patients exhibited 23% smaller bilateral bulb volume than comparison subjects, independent of acute clinical, demographic, or treatment measures. Bulb volume correlated with odor detection sensitivity in healthy subjects but not in patients with schizophrenia. Conclusions: Patients with schizophrenia exhibit structural olfactory deficits as well as functional olfactory deficits. The olfactory system may be a model system in which to study the neurobiology of the disorder.

Original languageEnglish (US)
Pages (from-to)828-830
Number of pages3
JournalAmerican Journal of Psychiatry
Volume157
Issue number5
DOIs
StatePublished - May 2000
Externally publishedYes

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Olfactory Bulb
Schizophrenia
Healthy Volunteers
Neurobiology
Magnetic Resonance Imaging
Demography

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Turetsky, B. I., Moberg, P. J., Yousem, D. M., Doty, R. L., Arnold, S. E., & Gur, R. E. (2000). Reduced olfactory bulb volume in patients with schizophrenia. American Journal of Psychiatry, 157(5), 828-830. https://doi.org/10.1176/appi.ajp.157.5.828

Reduced olfactory bulb volume in patients with schizophrenia. / Turetsky, Bruce I.; Moberg, Paul J.; Yousem, David Mark; Doty, Richard L.; Arnold, Steven E.; Gur, Raquel E.

In: American Journal of Psychiatry, Vol. 157, No. 5, 05.2000, p. 828-830.

Research output: Contribution to journalArticle

Turetsky, BI, Moberg, PJ, Yousem, DM, Doty, RL, Arnold, SE & Gur, RE 2000, 'Reduced olfactory bulb volume in patients with schizophrenia', American Journal of Psychiatry, vol. 157, no. 5, pp. 828-830. https://doi.org/10.1176/appi.ajp.157.5.828
Turetsky, Bruce I. ; Moberg, Paul J. ; Yousem, David Mark ; Doty, Richard L. ; Arnold, Steven E. ; Gur, Raquel E. / Reduced olfactory bulb volume in patients with schizophrenia. In: American Journal of Psychiatry. 2000 ; Vol. 157, No. 5. pp. 828-830.
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