Reduced miR-490-3p expression is associated with poor prognosis of Helicobacter pylori induced gastric cancer

M. Qu, Ling Li, W. C. Zheng

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Helicobacter pylori (HP) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (GC). The aim of the present study was to investigate the clinical significance of miR-490-3p in HP associated GC.

PATIENTS AND METHODS: We measured the expression level of miR-490-3p in human GC tissues by quantitative Real-time PCR (qPCR). Then the association between miR-490-3p and clinical features of GC was further investigated.

RESULTS: Our results showed that miR-490-3p levels exhibited a progressive downregulation in gastritis, intestinal metaplasia, HP negative GC and HP positive GC. In addition, miR-490-3p expression was significantly correlated with various clinicopathological parameters such as lymph node metastasis and clinical stage in HP-positive GC. Moreover, GC patients with lower miR-490-3p had a shorter 5 years overall/disease free survival time in the HP positive cohort. Finally, multivariate analysis showed that low miR-490-3p was an independent risk factor for HP associated GC.

CONCLUSIONS: miR-490-3p is downregulated in HP-positive GC and associated with poor clinical outcome, indicating that miR-490-3p is a promising prognostic biomarker for HP positive GC.

Original languageEnglish (US)
Pages (from-to)3384-3388
Number of pages5
JournalEuropean review for medical and pharmacological sciences
Volume21
Issue number15
StatePublished - Aug 1 2017
Externally publishedYes

Fingerprint

Helicobacter pylori
Stomach Neoplasms
Down-Regulation
Metaplasia
Helicobacter Infections
Gastritis
Disease-Free Survival
Real-Time Polymerase Chain Reaction
Multivariate Analysis
Biomarkers
Lymph Nodes
Neoplasm Metastasis

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Reduced miR-490-3p expression is associated with poor prognosis of Helicobacter pylori induced gastric cancer. / Qu, M.; Li, Ling; Zheng, W. C.

In: European review for medical and pharmacological sciences, Vol. 21, No. 15, 01.08.2017, p. 3384-3388.

Research output: Contribution to journalArticle

@article{232f238ad6384326b64f8346d9aa067b,
title = "Reduced miR-490-3p expression is associated with poor prognosis of Helicobacter pylori induced gastric cancer",
abstract = "OBJECTIVE: Helicobacter pylori (HP) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (GC). The aim of the present study was to investigate the clinical significance of miR-490-3p in HP associated GC.PATIENTS AND METHODS: We measured the expression level of miR-490-3p in human GC tissues by quantitative Real-time PCR (qPCR). Then the association between miR-490-3p and clinical features of GC was further investigated.RESULTS: Our results showed that miR-490-3p levels exhibited a progressive downregulation in gastritis, intestinal metaplasia, HP negative GC and HP positive GC. In addition, miR-490-3p expression was significantly correlated with various clinicopathological parameters such as lymph node metastasis and clinical stage in HP-positive GC. Moreover, GC patients with lower miR-490-3p had a shorter 5 years overall/disease free survival time in the HP positive cohort. Finally, multivariate analysis showed that low miR-490-3p was an independent risk factor for HP associated GC.CONCLUSIONS: miR-490-3p is downregulated in HP-positive GC and associated with poor clinical outcome, indicating that miR-490-3p is a promising prognostic biomarker for HP positive GC.",
author = "M. Qu and Ling Li and Zheng, {W. C.}",
year = "2017",
month = "8",
day = "1",
language = "English (US)",
volume = "21",
pages = "3384--3388",
journal = "European Review for Medical and Pharmacological Sciences",
issn = "1128-3602",
publisher = "Verduci Editore",
number = "15",

}

TY - JOUR

T1 - Reduced miR-490-3p expression is associated with poor prognosis of Helicobacter pylori induced gastric cancer

AU - Qu, M.

AU - Li, Ling

AU - Zheng, W. C.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - OBJECTIVE: Helicobacter pylori (HP) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (GC). The aim of the present study was to investigate the clinical significance of miR-490-3p in HP associated GC.PATIENTS AND METHODS: We measured the expression level of miR-490-3p in human GC tissues by quantitative Real-time PCR (qPCR). Then the association between miR-490-3p and clinical features of GC was further investigated.RESULTS: Our results showed that miR-490-3p levels exhibited a progressive downregulation in gastritis, intestinal metaplasia, HP negative GC and HP positive GC. In addition, miR-490-3p expression was significantly correlated with various clinicopathological parameters such as lymph node metastasis and clinical stage in HP-positive GC. Moreover, GC patients with lower miR-490-3p had a shorter 5 years overall/disease free survival time in the HP positive cohort. Finally, multivariate analysis showed that low miR-490-3p was an independent risk factor for HP associated GC.CONCLUSIONS: miR-490-3p is downregulated in HP-positive GC and associated with poor clinical outcome, indicating that miR-490-3p is a promising prognostic biomarker for HP positive GC.

AB - OBJECTIVE: Helicobacter pylori (HP) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (GC). The aim of the present study was to investigate the clinical significance of miR-490-3p in HP associated GC.PATIENTS AND METHODS: We measured the expression level of miR-490-3p in human GC tissues by quantitative Real-time PCR (qPCR). Then the association between miR-490-3p and clinical features of GC was further investigated.RESULTS: Our results showed that miR-490-3p levels exhibited a progressive downregulation in gastritis, intestinal metaplasia, HP negative GC and HP positive GC. In addition, miR-490-3p expression was significantly correlated with various clinicopathological parameters such as lymph node metastasis and clinical stage in HP-positive GC. Moreover, GC patients with lower miR-490-3p had a shorter 5 years overall/disease free survival time in the HP positive cohort. Finally, multivariate analysis showed that low miR-490-3p was an independent risk factor for HP associated GC.CONCLUSIONS: miR-490-3p is downregulated in HP-positive GC and associated with poor clinical outcome, indicating that miR-490-3p is a promising prognostic biomarker for HP positive GC.

UR - http://www.scopus.com/inward/record.url?scp=85049521094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049521094&partnerID=8YFLogxK

M3 - Article

C2 - 28829504

AN - SCOPUS:85049521094

VL - 21

SP - 3384

EP - 3388

JO - European Review for Medical and Pharmacological Sciences

JF - European Review for Medical and Pharmacological Sciences

SN - 1128-3602

IS - 15

ER -