Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders

Leah Rubin, C. Sue Carter, Jeffrey R. Bishop, Hossein Pournajafi-Nazarloo, Lauren L. Drogos, S. Kristian Hill, Anthony C. Ruocco, Sarah K. Keedy, James L. Reilly, Matcheri S. Keshavan, Godfrey D. Pearlson, Carol A. Tamminga, Elliot S. Gershon, John A. Sweeney

Research output: Contribution to journalArticle

Abstract

Oxytocin (OT) and arginine vasopressin (AVP) exert robust influence on social affiliation and specific cognitive processes in healthy individuals. Abnormalities in these neuroendocrine systems have been observed in psychotic disorders, but their relation to impairments in behavioral domains that these endocrines modulate is not well understood. We compared abnormalities of OT and AVP serum concentrations in probands with schizophrenia (n = 57), schizoaffective disorder (n = 34), and psychotic bipolar disorder (n = 75); their first-degree relatives without a history of psychosis (n = 61, 43, 91, respectively); and healthy controls (n = 66) and examined their association with emotion processing and cognition. AVP levels were lower in schizophrenia (P =. 002) and bipolar probands (P =. 03) and in relatives of schizophrenia probands (P =. 002) compared with controls. OT levels did not differ between groups. Familiality estimates were robust for OT (h 2 = 0.79, P = 3.97e-15) and AVP (h 2 = 0.78, P = 3.93e-11). Higher levels of OT were associated with better emotion recognition (β = 0.40, P

Original languageEnglish (US)
Pages (from-to)1374-1384
Number of pages11
JournalSchizophrenia Bulletin
Volume40
Issue number6
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

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Oxytocin
Vasopressins
Psychotic Disorders
Arginine Vasopressin
Schizophrenia
Emotions
Neurosecretory Systems
Bipolar Disorder
Cognition
Serum

Keywords

  • bipolar disorder
  • emotion recognition
  • oxytocin/vasopressin
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Rubin, L., Sue Carter, C., Bishop, J. R., Pournajafi-Nazarloo, H., Drogos, L. L., Kristian Hill, S., ... Sweeney, J. A. (2014). Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophrenia Bulletin, 40(6), 1374-1384. https://doi.org/10.1093/schbul/sbu027

Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. / Rubin, Leah; Sue Carter, C.; Bishop, Jeffrey R.; Pournajafi-Nazarloo, Hossein; Drogos, Lauren L.; Kristian Hill, S.; Ruocco, Anthony C.; Keedy, Sarah K.; Reilly, James L.; Keshavan, Matcheri S.; Pearlson, Godfrey D.; Tamminga, Carol A.; Gershon, Elliot S.; Sweeney, John A.

In: Schizophrenia Bulletin, Vol. 40, No. 6, 01.11.2014, p. 1374-1384.

Research output: Contribution to journalArticle

Rubin, L, Sue Carter, C, Bishop, JR, Pournajafi-Nazarloo, H, Drogos, LL, Kristian Hill, S, Ruocco, AC, Keedy, SK, Reilly, JL, Keshavan, MS, Pearlson, GD, Tamminga, CA, Gershon, ES & Sweeney, JA 2014, 'Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders', Schizophrenia Bulletin, vol. 40, no. 6, pp. 1374-1384. https://doi.org/10.1093/schbul/sbu027
Rubin L, Sue Carter C, Bishop JR, Pournajafi-Nazarloo H, Drogos LL, Kristian Hill S et al. Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophrenia Bulletin. 2014 Nov 1;40(6):1374-1384. https://doi.org/10.1093/schbul/sbu027
Rubin, Leah ; Sue Carter, C. ; Bishop, Jeffrey R. ; Pournajafi-Nazarloo, Hossein ; Drogos, Lauren L. ; Kristian Hill, S. ; Ruocco, Anthony C. ; Keedy, Sarah K. ; Reilly, James L. ; Keshavan, Matcheri S. ; Pearlson, Godfrey D. ; Tamminga, Carol A. ; Gershon, Elliot S. ; Sweeney, John A. / Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. In: Schizophrenia Bulletin. 2014 ; Vol. 40, No. 6. pp. 1374-1384.
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