TY - JOUR
T1 - Reduced intrasubject variability with reinforcement in boys, but not girls, with ADHD
T2 - Associations with prefrontal anatomy
AU - Rosch, Keri S.
AU - Dirlikov, Benjamin
AU - Mostofsky, Stewart H.
N1 - Funding Information:
This work was supported by NIH/NINDS: RO1 MH078160; RO1 MH085328, K23 MH101322, and the Johns Hopkins University, School of Medicine, Institute for Clinical and Translational Research, National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award program UL1 TR 000424-06, and was carried out in part at the F.M. Kirby Center for Functional Brain Imaging, using resources provided under P41 EB015909.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - This study examined the impact of motivational contingencies (reinforcement and punishment) on go/no-go (GNG) task performance in girls and boys with ADHD relative to typically developing (TD) children and associations with prefrontal anatomy. Children ages 8-12 with ADHD (n= 107, 36 girls) and TD controls (n= 95, 34 girls) completed a standard and a motivational GNG task and associations with prefrontal cortex (PFC) surface area were examined. Intrasubject variability (ISV) was lower during the motivational compared to the standard GNG among TD girls and boys, and boys with ADHD, but not among girls with ADHD. A greater reduction in ISV was associated with greater PFC surface area among children with ADHD. This novel demonstration of improvement in ISV with motivational contingencies for boys, but not girls, with ADHD and associations with PFC anatomy informs our understanding of sex differences and motivational factors contributing to ISV in children with ADHD.
AB - This study examined the impact of motivational contingencies (reinforcement and punishment) on go/no-go (GNG) task performance in girls and boys with ADHD relative to typically developing (TD) children and associations with prefrontal anatomy. Children ages 8-12 with ADHD (n= 107, 36 girls) and TD controls (n= 95, 34 girls) completed a standard and a motivational GNG task and associations with prefrontal cortex (PFC) surface area were examined. Intrasubject variability (ISV) was lower during the motivational compared to the standard GNG among TD girls and boys, and boys with ADHD, but not among girls with ADHD. A greater reduction in ISV was associated with greater PFC surface area among children with ADHD. This novel demonstration of improvement in ISV with motivational contingencies for boys, but not girls, with ADHD and associations with PFC anatomy informs our understanding of sex differences and motivational factors contributing to ISV in children with ADHD.
KW - ADHD
KW - Cognition
KW - Intrasubject variability
KW - Motivation
KW - Prefrontal cortex
KW - Response control
KW - Sex differences
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U2 - 10.1016/j.biopsycho.2015.06.010
DO - 10.1016/j.biopsycho.2015.06.010
M3 - Article
C2 - 26141238
AN - SCOPUS:84937116107
VL - 110
SP - 12
EP - 23
JO - Biological Psychology
JF - Biological Psychology
SN - 0019-493X
ER -