Abstract
Context: Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by a deficit in behavioral inhibition. Recent evidence also suggests a deficit in cortical inhibition via the GABA (γ- aminobutyric acid)-ergic system. Objective: To investigate the GABAergic component of ADHD using magnetic resonance spectroscopy. Design: Cross-sectional study. Setting: Participants were recruited through local schools, local pediatric and other community clinics, and through advertisement in regional publications. Magnetic resonance spectroscopy was performed within the research institute. Participants: Children (age range, 8-12 years) in a typically developing control group vs a group with ADHD were compared. Main Outcome Measures: J-difference-edited magnetic resonance spectroscopy at 3 T was used to measure GABA concentration in a volume that included primary somatosensory and motor cortices. Results: GABA concentration is reduced in children with ADHD compared with typically developing control subjects. Conclusion: Our finding of reduced GABA concentration in ADHD is concordant with recently reported deficits in short intracortical inhibition in ADHD and suggests a GABAergic deficit in ADHD.
Original language | English (US) |
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Pages (from-to) | 750-753 |
Number of pages | 4 |
Journal | Archives of general psychiatry |
Volume | 69 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2012 |
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Psychiatry and Mental health