Abstract
BACKGROUND: Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodeficiency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and -uninfected AGEhIV cohort participants. METHODS: Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. RESULTS: The unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and -uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modification whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. This resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. CONCLUSIONS: The lower FVC in HIV-infected participants could indicate HIV-related restrictive or fibrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure. CLINICAL TRIALS REGISTRATION: NCT01466582.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1274-1284 |
| Number of pages | 11 |
| Journal | The Journal of infectious diseases |
| Volume | 219 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 8 2019 |
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Keywords
- chronic obstructive
- HIV infection
- pulmonary disease
- pulmonary fibrosis
- respiratory function tests
- spirometry
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
Reduced Forced Vital Capacity Among Human Immunodeficiency Virus-Infected Middle-Aged Individuals. / AGEhIV Study Group .
In: The Journal of infectious diseases, Vol. 219, No. 8, 08.04.2019, p. 1274-1284.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced Forced Vital Capacity Among Human Immunodeficiency Virus-Infected Middle-Aged Individuals
AU - AGEhIV Study Group
AU - Verboeket, Sebastiaan O.
AU - Wit, Ferdinand W.
AU - Kirk, Gregory D
AU - Drummond, M. Bradley
AU - van Steenwijk, Reindert P.
AU - van Zoest, Rosan A.
AU - Nellen, Jeannine F.
AU - Schim van der Loeff, Maarten F.
AU - Reiss, Peter
PY - 2019/4/8
Y1 - 2019/4/8
N2 - BACKGROUND: Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodeficiency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and -uninfected AGEhIV cohort participants. METHODS: Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. RESULTS: The unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and -uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modification whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. This resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. CONCLUSIONS: The lower FVC in HIV-infected participants could indicate HIV-related restrictive or fibrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure. CLINICAL TRIALS REGISTRATION: NCT01466582.
AB - BACKGROUND: Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodeficiency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and -uninfected AGEhIV cohort participants. METHODS: Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. RESULTS: The unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and -uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modification whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. This resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. CONCLUSIONS: The lower FVC in HIV-infected participants could indicate HIV-related restrictive or fibrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure. CLINICAL TRIALS REGISTRATION: NCT01466582.
KW - chronic obstructive
KW - HIV infection
KW - pulmonary disease
KW - pulmonary fibrosis
KW - respiratory function tests
KW - spirometry
UR - http://www.scopus.com/inward/record.url?scp=85064487449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064487449&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiy653
DO - 10.1093/infdis/jiy653
M3 - Article
C2 - 30418599
AN - SCOPUS:85064487449
VL - 219
SP - 1274
EP - 1284
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 8
ER -