Reduced forced vital capacity among human immunodeficiency virus-infected middle-aged individuals

Sebastiaan O. Verboeket, Ferdinand W. Wit, Greg D. Kirk, M. Bradley Drummond, Reindert P. Van Steenwijk, Rosan A. Van Zoest, Jeannine F. Nellen, Maarten F.Schim Van Der Loeff, Peter Reiss

Research output: Contribution to journalArticlepeer-review


Background. Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodefciency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and-uninfected AGEhIV cohort participants. Methods. Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. Results. Te unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and-uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modifcation whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. Tis resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. Conclusions. Te lower FVC in HIV-infected participants could indicate HIV-related restrictive or fbrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure.

Original languageEnglish (US)
Pages (from-to)1274-1284
Number of pages11
JournalJournal of Infectious Diseases
Issue number8
StatePublished - Apr 8 2019


  • Chronic obstructive
  • HIV infection
  • Pulmonary disease
  • Pulmonary fbrosis
  • Respiratory function tests
  • Spirometry

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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