@article{879787e84e6a4f5ba2fbf1f9eae5c3db,
title = "Reduced forced vital capacity among human immunodeficiency virus-infected middle-aged individuals",
abstract = "Background. Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodefciency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and-uninfected AGEhIV cohort participants. Methods. Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. Results. Te unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and-uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modifcation whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. Tis resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. Conclusions. Te lower FVC in HIV-infected participants could indicate HIV-related restrictive or fbrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure.",
keywords = "Chronic obstructive, HIV infection, Pulmonary disease, Pulmonary fbrosis, Respiratory function tests, Spirometry",
author = "Verboeket, {Sebastiaan O.} and Wit, {Ferdinand W.} and Kirk, {Greg D.} and {Bradley Drummond}, M. and {Van Steenwijk}, {Reindert P.} and {Van Zoest}, {Rosan A.} and Nellen, {Jeannine F.} and {Van Der Loeff}, {Maarten F.Schim} and Peter Reiss",
note = "Funding Information: Financial support. This work was supported by The Netherlands Organization for Health Research and Development (grant number 300020007) and AIDS Fonds (grant number 2009063). Additional unrestricted scientific grants were received from Gilead Sciences, ViiV Healthcare, Janssen Pharmaceuticals N.V., and Merck & Co. Potential conflicts of interest. S. O. V., R. A. v. Z., and P. R. through their institution have received independent scientific grant support from Gilead Sciences, Janssen Pharmaceuticals, Merck & Co, and ViiV Healthcare. F. W. W. has served on scientific advisory boards for ViiV Healthcare and Gilead Sciences. R. P. v. S. has no potential conflicts of interest related to this manuscript. G. D. K. was supported by a Fulbright Global Scholar award (US Department of State) and by the National Institute of Allergy and Infectious Diseases (grant number K24-AI118591). M. B. D. has participated in advisory consulting for Boehringen-Ingelheim, GlaxoSmithKline, and AstraZeneca. R. A. v. Z. has received travel grants from Gilead Sciences and was a speaker at an event sponsored by Gilead Sciences for which her institution received remuneration. J. F. N. has participated in educational activities for ViiV Healthcare, Gilead Sciences, and BMS for which her institution has received remuneration. M. F. S. v. d. L. has received independent scientific grant support from Sanofi Pasteur, MSD Janssen Infectious Diseases and Vaccines, and Merck; has served on the advisory board of GSK; and has received nonfinancial support from Stichting Pathologie Onderzoek en Ontwikkeling. P. R. has served on scientific advisory boards for Gilead Sciences, ViiV Healthcare, Merck & Co, and Teva Pharmaceutical Industries; and has served on a data and safety monitoring committee for Janssen Pharmaceuticals, for which his institution has received remuneration. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2019",
month = apr,
day = "8",
doi = "10.1093/infdis/jiy653",
language = "English (US)",
volume = "219",
pages = "1274--1284",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "8",
}