Reduced Forced Vital Capacity Among Human Immunodeficiency Virus-Infected Middle-Aged Individuals

AGEhIV Study Group

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodeficiency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and -uninfected AGEhIV cohort participants. METHODS: Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. RESULTS: The unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and -uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modification whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. This resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. CONCLUSIONS: The lower FVC in HIV-infected participants could indicate HIV-related restrictive or fibrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure. CLINICAL TRIALS REGISTRATION: NCT01466582.

Original languageEnglish (US)
Pages (from-to)1274-1284
Number of pages11
JournalThe Journal of infectious diseases
Volume219
Issue number8
DOIs
StatePublished - Apr 8 2019

Fingerprint

Vital Capacity
HIV
Obstructive Lung Diseases
Lung
Risk-Taking
Logistic Models
Smoking
Spirometry
Forced Expiratory Volume
Virus Diseases
Life Style
Regression Analysis
Clinical Trials

Keywords

  • chronic obstructive
  • HIV infection
  • pulmonary disease
  • pulmonary fibrosis
  • respiratory function tests
  • spirometry

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Reduced Forced Vital Capacity Among Human Immunodeficiency Virus-Infected Middle-Aged Individuals. / AGEhIV Study Group .

In: The Journal of infectious diseases, Vol. 219, No. 8, 08.04.2019, p. 1274-1284.

Research output: Contribution to journalArticle

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title = "Reduced Forced Vital Capacity Among Human Immunodeficiency Virus-Infected Middle-Aged Individuals",
abstract = "BACKGROUND: Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodeficiency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and -uninfected AGEhIV cohort participants. METHODS: Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. RESULTS: The unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0{\%}) and -uninfected (23.4{\%}) participants. Multivariable logistic regression analysis showed an effect modification whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. This resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. CONCLUSIONS: The lower FVC in HIV-infected participants could indicate HIV-related restrictive or fibrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure. CLINICAL TRIALS REGISTRATION: NCT01466582.",
keywords = "chronic obstructive, HIV infection, pulmonary disease, pulmonary fibrosis, respiratory function tests, spirometry",
author = "{AGEhIV Study Group} and Verboeket, {Sebastiaan O.} and Wit, {Ferdinand W.} and Kirk, {Gregory D} and Drummond, {M. Bradley} and {van Steenwijk}, {Reindert P.} and {van Zoest}, {Rosan A.} and Nellen, {Jeannine F.} and {Schim van der Loeff}, {Maarten F.} and Peter Reiss",
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T1 - Reduced Forced Vital Capacity Among Human Immunodeficiency Virus-Infected Middle-Aged Individuals

AU - AGEhIV Study Group

AU - Verboeket, Sebastiaan O.

AU - Wit, Ferdinand W.

AU - Kirk, Gregory D

AU - Drummond, M. Bradley

AU - van Steenwijk, Reindert P.

AU - van Zoest, Rosan A.

AU - Nellen, Jeannine F.

AU - Schim van der Loeff, Maarten F.

AU - Reiss, Peter

PY - 2019/4/8

Y1 - 2019/4/8

N2 - BACKGROUND: Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodeficiency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and -uninfected AGEhIV cohort participants. METHODS: Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. RESULTS: The unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and -uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modification whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. This resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. CONCLUSIONS: The lower FVC in HIV-infected participants could indicate HIV-related restrictive or fibrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure. CLINICAL TRIALS REGISTRATION: NCT01466582.

AB - BACKGROUND: Pulmonary function impairments are more common among people living with HIV (PLWH), as are contributing risk behaviors. To understand the effects of human immunodeficiency virus (HIV) infection independent of risk behaviors, pulmonary function was evaluated in lifestyle-comparable HIV-infected and -uninfected AGEhIV cohort participants. METHODS: Prevalence of obstructive lung disease in 544 HIV-infected and 529 HIV-uninfected participants was determined using spirometry. Logistic regression was used to assess HIV as a determinant of obstructive lung disease. Additional explanatory models were constructed to explain observed differences. RESULTS: The unadjusted obstructive lung disease prevalence was similar in HIV-infected (23.0%) and -uninfected (23.4%) participants. Multivariable logistic regression analysis showed an effect modification whereby obstructive lung disease prevalence among persons with limited smoking experience was notably lower among HIV-infected compared with HIV-uninfected participants. This resulted from a lower forced vital capacity (FVC) in HIV-infected participants but similar 1-second forced expiratory volume (FEV1), especially in those with limited smoking experience. CONCLUSIONS: The lower FVC in HIV-infected participants could indicate HIV-related restrictive or fibrotic pulmonary changes. Factors that decrease the FVC could obscure emphysematous changes in the lungs of PLWH when using the FEV1/FVC ratio as single diagnostic measure. CLINICAL TRIALS REGISTRATION: NCT01466582.

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