Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

Thomas M. Loftus, Donna E. Jaworsky, Cojeb L. Frehywot, Craig A. Townsend, Gabriele V. Ronnett, M. Daniel Lane, Francis P. Kuhajda

Research output: Contribution to journalArticlepeer-review

Abstract

With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body weight. We have identified a link between anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) led to inhibition of feeding and dramatic weight loss. C75 inhibited expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin-independent manner that appears to be mediated by malonyl-coenzyme A. Thus, FAS may represent an important link in feeding regulation and may be a potential therapeutic target.

Original languageEnglish (US)
Pages (from-to)2379-2381
Number of pages3
JournalScience
Volume288
Issue number5475
DOIs
StatePublished - Jun 30 2000

ASJC Scopus subject areas

  • General

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