Abstract
With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body weight. We have identified a link between anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) led to inhibition of feeding and dramatic weight loss. C75 inhibited expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin-independent manner that appears to be mediated by malonyl-coenzyme A. Thus, FAS may represent an important link in feeding regulation and may be a potential therapeutic target.
Original language | English (US) |
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Pages (from-to) | 2379-2381 |
Number of pages | 3 |
Journal | Science |
Volume | 288 |
Issue number | 5475 |
DOIs | |
State | Published - Jun 30 2000 |
ASJC Scopus subject areas
- General