TY - JOUR
T1 - Reduced Field-of-View Diffusion-Weighted Imaging in Histological Characterization of Rectal Cancer
T2 - Impact of Different Region-of-Interest Positioning Protocols on Apparent Diffusion Coefficient Measurements
AU - Yang, Peng
AU - Xu, Chuou
AU - Hu, Xuemei
AU - Shen, Yaqi
AU - Hu, Daoyu
AU - Kamel, Ihab
AU - Li, Zhen
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/6
Y1 - 2020/6
N2 - Purpose: To compare four region-of-interest (ROI) protocols for apparent diffusion coefficient (ADC) quantifications derived from reduced field-of-view diffusion-weighted imaging (rDWI) in histological characterization of rectal cancer. Materials and methods: Forty-nine patients with rectal cancer underwent rDWI at 3.0 T. Two readers independently performed mean and minimum ADC measurements using four different ROI positioning protocols (whole tumor volume [WTV], single-slice [SS], three-slices observer-based sampling [TSOB] and three-slices predefined sampling [TSPD]). Inter-observer variation was evaluated. Mean and minimum ADC values obtained from each method were compared in terms of different histological factors of rectal cancer, and their diagnostic abilities were assessed by receiver operating characteristic curve (ROC) analysis. The corresponding times for ADC measurements were recorded and compared between ROI methods. Results: The inter-observer agreement was excellent for ADC values obtained by two readers using the four ROI methods (ICC range, 0.906-0.994). Mean and minimum ADC values by WTV method were significantly higher and lower than other methods respectively for both readers (P < 0.05). The AUCs of mean ADC measurements for assessment of well-differentiated tumors, T2 stage tumors and N0 status (no lymph node metastasis) (0.936, 0.840 and 0.714) were greater by WTV method than those by SS method (0.782, 0.761 and 0.677). The WTV method required longer measurement time than other ROI methods (P < 0.001). Conclusion: ADC measurements based on rDWI were influenced by ROI positioning protocols. rDWI technique had diagnostic value for histological characterization of rectal cancer, using WTV method with overall best inter-observer reproducibility, but with the longest measurement time.
AB - Purpose: To compare four region-of-interest (ROI) protocols for apparent diffusion coefficient (ADC) quantifications derived from reduced field-of-view diffusion-weighted imaging (rDWI) in histological characterization of rectal cancer. Materials and methods: Forty-nine patients with rectal cancer underwent rDWI at 3.0 T. Two readers independently performed mean and minimum ADC measurements using four different ROI positioning protocols (whole tumor volume [WTV], single-slice [SS], three-slices observer-based sampling [TSOB] and three-slices predefined sampling [TSPD]). Inter-observer variation was evaluated. Mean and minimum ADC values obtained from each method were compared in terms of different histological factors of rectal cancer, and their diagnostic abilities were assessed by receiver operating characteristic curve (ROC) analysis. The corresponding times for ADC measurements were recorded and compared between ROI methods. Results: The inter-observer agreement was excellent for ADC values obtained by two readers using the four ROI methods (ICC range, 0.906-0.994). Mean and minimum ADC values by WTV method were significantly higher and lower than other methods respectively for both readers (P < 0.05). The AUCs of mean ADC measurements for assessment of well-differentiated tumors, T2 stage tumors and N0 status (no lymph node metastasis) (0.936, 0.840 and 0.714) were greater by WTV method than those by SS method (0.782, 0.761 and 0.677). The WTV method required longer measurement time than other ROI methods (P < 0.001). Conclusion: ADC measurements based on rDWI were influenced by ROI positioning protocols. rDWI technique had diagnostic value for histological characterization of rectal cancer, using WTV method with overall best inter-observer reproducibility, but with the longest measurement time.
KW - Diffusion magnetic resonance imaging
KW - Magnetic resonance imaging
KW - Rectal neoplasms
KW - Region of interest
KW - Reproducibility
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U2 - 10.1016/j.ejrad.2020.109028
DO - 10.1016/j.ejrad.2020.109028
M3 - Article
C2 - 32361587
AN - SCOPUS:85083882990
SN - 0720-048X
VL - 127
JO - European Journal of Radiology
JF - European Journal of Radiology
M1 - 109028
ER -