Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer

Daisuke Nonaka, Alessandra Fabbri, Luca Roz, Luigi Mariani, Andrea Vecchione, G. William Moore, Luca Tavecchio, Carlo M. Croce, Gabriella Sozzi

Research output: Contribution to journalArticle

Abstract

Chromosomal deletions are often observed in lung cancers suggesting that inactivation of tumor suppressor genes plays an important role in the development of this neoplasm. The region around chromosome 8p22 is a frequent and early target of these deletions and has therefore been investigated for the presence of candidate genes. The FEZ1/LZTS1 gene, located at 8p22, is inactivated in many cancers with 8p deletions, including prostate, esophageal, gastric, bladder, and breast cancer and the Fez1 protein has been shown to suppress growth of cancer cells and to regulate mitosis. To elucidate the role of FEZ1 in lung cancer, we have analyzed its expression by immunohistochemistry in 103 primary lung cancer specimens including 98 non-small cell lung cancers (57 adenocarcinomas, 32 squamous cell carcinomas, 7 large cell carcinomas, and 2 others) and five small cell carcinomas. Absence of Fez1 protein expression was observed in 27 cases (26%) and additional 43 cases (42%) showed strong reduction in immunoreactivity. There was a positive association between loss of FEZ1 expression and tumor grading (P = 0.0345) and a tendency toward a reduction in the mortality rate in subjects with strong FEZ1 expression. Overall, these data indicate an important role for FEZ1 in lung cancer and suggest the possibility that it may serve as a novel prognostic indicator.

Original languageEnglish (US)
Pages (from-to)1207-1212
Number of pages6
JournalCancer Research
Volume65
Issue number4
DOIs
StatePublished - Feb 15 2005
Externally publishedYes

Fingerprint

Lung Neoplasms
Large Cell Carcinoma
Neoplasms
Small Cell Carcinoma
Neoplasm Grading
Esophageal Neoplasms
Tumor Suppressor Genes
Mitosis
Urinary Bladder Neoplasms
Non-Small Cell Lung Carcinoma
Genes
Stomach Neoplasms
Squamous Cell Carcinoma
Prostatic Neoplasms
Proteins
Adenocarcinoma
Chromosomes
Immunohistochemistry
Breast Neoplasms
Mortality

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nonaka, D., Fabbri, A., Roz, L., Mariani, L., Vecchione, A., Moore, G. W., ... Sozzi, G. (2005). Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. Cancer Research, 65(4), 1207-1212. https://doi.org/10.1158/0008-5472.CAN-04-3461

Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. / Nonaka, Daisuke; Fabbri, Alessandra; Roz, Luca; Mariani, Luigi; Vecchione, Andrea; Moore, G. William; Tavecchio, Luca; Croce, Carlo M.; Sozzi, Gabriella.

In: Cancer Research, Vol. 65, No. 4, 15.02.2005, p. 1207-1212.

Research output: Contribution to journalArticle

Nonaka, D, Fabbri, A, Roz, L, Mariani, L, Vecchione, A, Moore, GW, Tavecchio, L, Croce, CM & Sozzi, G 2005, 'Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer', Cancer Research, vol. 65, no. 4, pp. 1207-1212. https://doi.org/10.1158/0008-5472.CAN-04-3461
Nonaka D, Fabbri A, Roz L, Mariani L, Vecchione A, Moore GW et al. Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. Cancer Research. 2005 Feb 15;65(4):1207-1212. https://doi.org/10.1158/0008-5472.CAN-04-3461
Nonaka, Daisuke ; Fabbri, Alessandra ; Roz, Luca ; Mariani, Luigi ; Vecchione, Andrea ; Moore, G. William ; Tavecchio, Luca ; Croce, Carlo M. ; Sozzi, Gabriella. / Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. In: Cancer Research. 2005 ; Vol. 65, No. 4. pp. 1207-1212.
@article{6c01ac9dfcca46169a9e65d7ae726977,
title = "Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer",
abstract = "Chromosomal deletions are often observed in lung cancers suggesting that inactivation of tumor suppressor genes plays an important role in the development of this neoplasm. The region around chromosome 8p22 is a frequent and early target of these deletions and has therefore been investigated for the presence of candidate genes. The FEZ1/LZTS1 gene, located at 8p22, is inactivated in many cancers with 8p deletions, including prostate, esophageal, gastric, bladder, and breast cancer and the Fez1 protein has been shown to suppress growth of cancer cells and to regulate mitosis. To elucidate the role of FEZ1 in lung cancer, we have analyzed its expression by immunohistochemistry in 103 primary lung cancer specimens including 98 non-small cell lung cancers (57 adenocarcinomas, 32 squamous cell carcinomas, 7 large cell carcinomas, and 2 others) and five small cell carcinomas. Absence of Fez1 protein expression was observed in 27 cases (26{\%}) and additional 43 cases (42{\%}) showed strong reduction in immunoreactivity. There was a positive association between loss of FEZ1 expression and tumor grading (P = 0.0345) and a tendency toward a reduction in the mortality rate in subjects with strong FEZ1 expression. Overall, these data indicate an important role for FEZ1 in lung cancer and suggest the possibility that it may serve as a novel prognostic indicator.",
author = "Daisuke Nonaka and Alessandra Fabbri and Luca Roz and Luigi Mariani and Andrea Vecchione and Moore, {G. William} and Luca Tavecchio and Croce, {Carlo M.} and Gabriella Sozzi",
year = "2005",
month = "2",
day = "15",
doi = "10.1158/0008-5472.CAN-04-3461",
language = "English (US)",
volume = "65",
pages = "1207--1212",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

TY - JOUR

T1 - Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer

AU - Nonaka, Daisuke

AU - Fabbri, Alessandra

AU - Roz, Luca

AU - Mariani, Luigi

AU - Vecchione, Andrea

AU - Moore, G. William

AU - Tavecchio, Luca

AU - Croce, Carlo M.

AU - Sozzi, Gabriella

PY - 2005/2/15

Y1 - 2005/2/15

N2 - Chromosomal deletions are often observed in lung cancers suggesting that inactivation of tumor suppressor genes plays an important role in the development of this neoplasm. The region around chromosome 8p22 is a frequent and early target of these deletions and has therefore been investigated for the presence of candidate genes. The FEZ1/LZTS1 gene, located at 8p22, is inactivated in many cancers with 8p deletions, including prostate, esophageal, gastric, bladder, and breast cancer and the Fez1 protein has been shown to suppress growth of cancer cells and to regulate mitosis. To elucidate the role of FEZ1 in lung cancer, we have analyzed its expression by immunohistochemistry in 103 primary lung cancer specimens including 98 non-small cell lung cancers (57 adenocarcinomas, 32 squamous cell carcinomas, 7 large cell carcinomas, and 2 others) and five small cell carcinomas. Absence of Fez1 protein expression was observed in 27 cases (26%) and additional 43 cases (42%) showed strong reduction in immunoreactivity. There was a positive association between loss of FEZ1 expression and tumor grading (P = 0.0345) and a tendency toward a reduction in the mortality rate in subjects with strong FEZ1 expression. Overall, these data indicate an important role for FEZ1 in lung cancer and suggest the possibility that it may serve as a novel prognostic indicator.

AB - Chromosomal deletions are often observed in lung cancers suggesting that inactivation of tumor suppressor genes plays an important role in the development of this neoplasm. The region around chromosome 8p22 is a frequent and early target of these deletions and has therefore been investigated for the presence of candidate genes. The FEZ1/LZTS1 gene, located at 8p22, is inactivated in many cancers with 8p deletions, including prostate, esophageal, gastric, bladder, and breast cancer and the Fez1 protein has been shown to suppress growth of cancer cells and to regulate mitosis. To elucidate the role of FEZ1 in lung cancer, we have analyzed its expression by immunohistochemistry in 103 primary lung cancer specimens including 98 non-small cell lung cancers (57 adenocarcinomas, 32 squamous cell carcinomas, 7 large cell carcinomas, and 2 others) and five small cell carcinomas. Absence of Fez1 protein expression was observed in 27 cases (26%) and additional 43 cases (42%) showed strong reduction in immunoreactivity. There was a positive association between loss of FEZ1 expression and tumor grading (P = 0.0345) and a tendency toward a reduction in the mortality rate in subjects with strong FEZ1 expression. Overall, these data indicate an important role for FEZ1 in lung cancer and suggest the possibility that it may serve as a novel prognostic indicator.

UR - http://www.scopus.com/inward/record.url?scp=13944274117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13944274117&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-04-3461

DO - 10.1158/0008-5472.CAN-04-3461

M3 - Article

C2 - 15735004

AN - SCOPUS:13944274117

VL - 65

SP - 1207

EP - 1212

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 4

ER -