Reduced expression of the BRCA1 gene and increased chromosomal instability in MCF-7 cell line

S. K. Kachhap, S. P. Vetale, P. Dange, S. N. Ghosh

Research output: Contribution to journalArticlepeer-review

Abstract

Using clonal cell cultures, a significant increase in chromosomal aberrations (aneuplolidy, dicentrics and chromatid breaks) were observed in MCF-7 cells compared with HeLa. BRCA1 expression was lower in MCF-7 cells than in HeLa cells. Since BRCA1 is known to play a role in the maintenance of chromosomal integrity, the increase in chromosomal aberrations in MCF-7 clones suggests that downregulation of BRCA1 expression could be one of the possible mechanisms for increased chromosomal instability in this cell line.

Original languageEnglish (US)
Pages (from-to)547-551
Number of pages5
JournalCell Biology International
Volume25
Issue number6
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • BRCA1 mRNA expression
  • Breast cancer cell line
  • Chromosomal instability

ASJC Scopus subject areas

  • Cell Biology

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