Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depression

S. Weis, I. C. Llenos, Sarven Sabunciyan, J. R. Dulay, L. Isler, Robert H Yolken, H. Perron

Research output: Contribution to journalArticle

Abstract

The human endogenous retrovirus (HERV)-W multicopy family was identified in human DNA from the previously characterized multiple sclerosis associated retroviral element (MSRV). Upregulation of the HERV-W POL has been reported in cerebrospinal fluid of patients with schizophrenia. The expression of capsid (GAG) protein of HERV-W was studied by immunohistochemistry and western blotting in postmortem brain tissue of the anterior cingulate cortex and hippocampal formation of normal controls and of patients with schizophrenia, bipolar disorder and major depression. A physiological expression of GAG protein was detected in neurons as well as astroglial cells in normal brain both in the anterior cingulate cortex and in the hippocampal formation. There was a statistically significant reduction of this expression in neurons and astroglial cells in brains from individuals with schizophrenia, major depression, and bipolar disorder. The results from the present study confirm that GAG protein encoded by the HERV-W multicopy gene family is expressed in cells of the central nervous system under normal conditions. Our findings of a cell type-, brain region- and disease-specific reduced expression in schizophrenia, major depression, and bipolar disorder are compatible with a pathophysiological role of HERVs in human brain disorders. The causes and biological consequences of this differential regulation will be the subject of further investigations.

Original languageEnglish (US)
Pages (from-to)645-655
Number of pages11
JournalJournal of Neural Transmission
Volume114
Issue number5
DOIs
StatePublished - May 2007

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Endogenous Retroviruses
Parahippocampal Gyrus
Gyrus Cinguli
Bipolar Disorder
Schizophrenia
Brain Diseases
Depression
Proteins
Hippocampus
Brain
Neurons
Capsid Proteins
Multiple Sclerosis
Cerebrospinal Fluid
Up-Regulation
Central Nervous System
Western Blotting
Immunohistochemistry
DNA
Genes

Keywords

  • Bipolar disorder
  • Glia
  • Human endogenous retrovirus-W (HERV-W)
  • Major depression
  • Neuron
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depression. / Weis, S.; Llenos, I. C.; Sabunciyan, Sarven; Dulay, J. R.; Isler, L.; Yolken, Robert H; Perron, H.

In: Journal of Neural Transmission, Vol. 114, No. 5, 05.2007, p. 645-655.

Research output: Contribution to journalArticle

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