Reduced cerebral blood flow in older men with higher levels of blood pressure

Shari R. Waldstein, David M. Lefkowitz, Eliot L. Siegel, William F. Rosenberger, Robert J. Spencer, Carol F. Tankard, Zorayr Manukyan, Evie J. Gerber, Leslie I. Katzel

Research output: Contribution to journalArticle

Abstract

Objective: To examine relations of blood pressure (BP) with single photon emission computed tomography (SPECT)-derived estimates of cerebral blood flow in older men and women. Methods: Seventy-four stroke and dementia-free, community-dwelling older adults (ages 54-83 years; 68% men; 91% white) free of major medical, neurological, or psychiatric disease, engaged in clinical assessment of resting SBP and DBP, MRI rated for brain atrophy, and brain single photon emission computed tomography (SPECT) studies with computerized coding of cortical and select subcortical regions of interest. Results: Given significant interactions of BP and sex with respect to multiple SPECT outcomes, sex-stratified multiple regression models were computed. Models were adjusted for age, fasting glucose levels, antihypertensive medication, BMI, and MRI ratings of brain atrophy. In men (n = 50), higher levels of SBP and/or DBP were associated significantly with lower estimates of cerebral perfusion in the right and left frontal, temporal, parietal, and occipital cortex, thalamus, head of caudate, and cingulate cortex accounting for up to 28% of the variance in these measures (P <0.05). In women (n = 24), higher DBP was related marginally to higher levels of perfusion in the right temporal cortex (P = 0.05). Conclusion: Higher resting SBP or DBP was associated with lower levels of cerebral perfusion in otherwise healthy older men, but not women, in the present sample. Reduced cerebral blood flow may play a pathogenic role in increasing risk for stroke, dementia, and/or cognitive decline, particularly among older men with high BP.

Original languageEnglish (US)
Pages (from-to)993-998
Number of pages6
JournalJournal of Hypertension
Volume28
Issue number5
DOIs
StatePublished - May 2010

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Cerebrovascular Circulation
Hypertension
Single-Photon Emission-Computed Tomography
Perfusion
Temporal Lobe
Atrophy
Dementia
Brain
Stroke
Blood Pressure
Independent Living
Occipital Lobe
Parietal Lobe
Gyrus Cinguli
Frontal Lobe
Thalamus
Antihypertensive Agents
Psychiatry
Fasting
Glucose

Keywords

  • Blood pressure
  • Brain single photon emission computed tomography
  • Cerebral blood flow
  • Cerebral perfusion
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Waldstein, S. R., Lefkowitz, D. M., Siegel, E. L., Rosenberger, W. F., Spencer, R. J., Tankard, C. F., ... Katzel, L. I. (2010). Reduced cerebral blood flow in older men with higher levels of blood pressure. Journal of Hypertension, 28(5), 993-998. https://doi.org/10.1097/HJH.0b013e328335c34f

Reduced cerebral blood flow in older men with higher levels of blood pressure. / Waldstein, Shari R.; Lefkowitz, David M.; Siegel, Eliot L.; Rosenberger, William F.; Spencer, Robert J.; Tankard, Carol F.; Manukyan, Zorayr; Gerber, Evie J.; Katzel, Leslie I.

In: Journal of Hypertension, Vol. 28, No. 5, 05.2010, p. 993-998.

Research output: Contribution to journalArticle

Waldstein, SR, Lefkowitz, DM, Siegel, EL, Rosenberger, WF, Spencer, RJ, Tankard, CF, Manukyan, Z, Gerber, EJ & Katzel, LI 2010, 'Reduced cerebral blood flow in older men with higher levels of blood pressure', Journal of Hypertension, vol. 28, no. 5, pp. 993-998. https://doi.org/10.1097/HJH.0b013e328335c34f
Waldstein SR, Lefkowitz DM, Siegel EL, Rosenberger WF, Spencer RJ, Tankard CF et al. Reduced cerebral blood flow in older men with higher levels of blood pressure. Journal of Hypertension. 2010 May;28(5):993-998. https://doi.org/10.1097/HJH.0b013e328335c34f
Waldstein, Shari R. ; Lefkowitz, David M. ; Siegel, Eliot L. ; Rosenberger, William F. ; Spencer, Robert J. ; Tankard, Carol F. ; Manukyan, Zorayr ; Gerber, Evie J. ; Katzel, Leslie I. / Reduced cerebral blood flow in older men with higher levels of blood pressure. In: Journal of Hypertension. 2010 ; Vol. 28, No. 5. pp. 993-998.
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abstract = "Objective: To examine relations of blood pressure (BP) with single photon emission computed tomography (SPECT)-derived estimates of cerebral blood flow in older men and women. Methods: Seventy-four stroke and dementia-free, community-dwelling older adults (ages 54-83 years; 68{\%} men; 91{\%} white) free of major medical, neurological, or psychiatric disease, engaged in clinical assessment of resting SBP and DBP, MRI rated for brain atrophy, and brain single photon emission computed tomography (SPECT) studies with computerized coding of cortical and select subcortical regions of interest. Results: Given significant interactions of BP and sex with respect to multiple SPECT outcomes, sex-stratified multiple regression models were computed. Models were adjusted for age, fasting glucose levels, antihypertensive medication, BMI, and MRI ratings of brain atrophy. In men (n = 50), higher levels of SBP and/or DBP were associated significantly with lower estimates of cerebral perfusion in the right and left frontal, temporal, parietal, and occipital cortex, thalamus, head of caudate, and cingulate cortex accounting for up to 28{\%} of the variance in these measures (P <0.05). In women (n = 24), higher DBP was related marginally to higher levels of perfusion in the right temporal cortex (P = 0.05). Conclusion: Higher resting SBP or DBP was associated with lower levels of cerebral perfusion in otherwise healthy older men, but not women, in the present sample. Reduced cerebral blood flow may play a pathogenic role in increasing risk for stroke, dementia, and/or cognitive decline, particularly among older men with high BP.",
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AU - Spencer, Robert J.

AU - Tankard, Carol F.

AU - Manukyan, Zorayr

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N2 - Objective: To examine relations of blood pressure (BP) with single photon emission computed tomography (SPECT)-derived estimates of cerebral blood flow in older men and women. Methods: Seventy-four stroke and dementia-free, community-dwelling older adults (ages 54-83 years; 68% men; 91% white) free of major medical, neurological, or psychiatric disease, engaged in clinical assessment of resting SBP and DBP, MRI rated for brain atrophy, and brain single photon emission computed tomography (SPECT) studies with computerized coding of cortical and select subcortical regions of interest. Results: Given significant interactions of BP and sex with respect to multiple SPECT outcomes, sex-stratified multiple regression models were computed. Models were adjusted for age, fasting glucose levels, antihypertensive medication, BMI, and MRI ratings of brain atrophy. In men (n = 50), higher levels of SBP and/or DBP were associated significantly with lower estimates of cerebral perfusion in the right and left frontal, temporal, parietal, and occipital cortex, thalamus, head of caudate, and cingulate cortex accounting for up to 28% of the variance in these measures (P <0.05). In women (n = 24), higher DBP was related marginally to higher levels of perfusion in the right temporal cortex (P = 0.05). Conclusion: Higher resting SBP or DBP was associated with lower levels of cerebral perfusion in otherwise healthy older men, but not women, in the present sample. Reduced cerebral blood flow may play a pathogenic role in increasing risk for stroke, dementia, and/or cognitive decline, particularly among older men with high BP.

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