Reduced central serotonin transporters in alcoholism

Andreas Heinz, Paul Ragan, Douglas W. Jones, Dan Hommer, Wendol Williams, Michael B. Knable, Julia G. Gorey, Linda Doty, Christopher Geyer, Kan S. Lee, Richard Coppola, Daniel Weinberger, Markku Linnoila

Research output: Contribution to journalArticle

Abstract

Objective: Dysfunction of monoamine uptake mechanisms has been implicated in the pathogenesis of alcohol dependence. The authors explored whether serotonergic dysfunction is associated with anxiety and depression, which increase the risk of relapse in alcoholics. Method: The availability of serotonin and dopamine transporters in 22 male alcoholics and 13 healthy male volunteers was measured with the use of [123I]β-CIT and single photon emission computed tomography, and psychopathological correlates were assessed. Results: A significant reduction (a mean of about 30%) in the availability of brainstem serotonin transporters was found in the alcoholics, which was significantly correlated with lifetime alcohol consumption and with ratings of depression and anxiety during withdrawal. Conclusions: The findings support the hypothesis of serotonergic dysfunction in alcoholism and in withdrawal-emergent depressive symptoms.

Original languageEnglish (US)
Pages (from-to)1544-1549
Number of pages6
JournalAmerican Journal of Psychiatry
Volume155
Issue number11
StatePublished - Nov 1998
Externally publishedYes

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Serotonin Plasma Membrane Transport Proteins
Alcoholics
Alcoholism
Depression
Anxiety
Dopamine Plasma Membrane Transport Proteins
Single-Photon Emission-Computed Tomography
Alcohol Drinking
Brain Stem
Healthy Volunteers
Recurrence

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Heinz, A., Ragan, P., Jones, D. W., Hommer, D., Williams, W., Knable, M. B., ... Linnoila, M. (1998). Reduced central serotonin transporters in alcoholism. American Journal of Psychiatry, 155(11), 1544-1549.

Reduced central serotonin transporters in alcoholism. / Heinz, Andreas; Ragan, Paul; Jones, Douglas W.; Hommer, Dan; Williams, Wendol; Knable, Michael B.; Gorey, Julia G.; Doty, Linda; Geyer, Christopher; Lee, Kan S.; Coppola, Richard; Weinberger, Daniel; Linnoila, Markku.

In: American Journal of Psychiatry, Vol. 155, No. 11, 11.1998, p. 1544-1549.

Research output: Contribution to journalArticle

Heinz, A, Ragan, P, Jones, DW, Hommer, D, Williams, W, Knable, MB, Gorey, JG, Doty, L, Geyer, C, Lee, KS, Coppola, R, Weinberger, D & Linnoila, M 1998, 'Reduced central serotonin transporters in alcoholism', American Journal of Psychiatry, vol. 155, no. 11, pp. 1544-1549.
Heinz A, Ragan P, Jones DW, Hommer D, Williams W, Knable MB et al. Reduced central serotonin transporters in alcoholism. American Journal of Psychiatry. 1998 Nov;155(11):1544-1549.
Heinz, Andreas ; Ragan, Paul ; Jones, Douglas W. ; Hommer, Dan ; Williams, Wendol ; Knable, Michael B. ; Gorey, Julia G. ; Doty, Linda ; Geyer, Christopher ; Lee, Kan S. ; Coppola, Richard ; Weinberger, Daniel ; Linnoila, Markku. / Reduced central serotonin transporters in alcoholism. In: American Journal of Psychiatry. 1998 ; Vol. 155, No. 11. pp. 1544-1549.
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AU - Doty, Linda

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