Reduced Brain Metabolism in Hyperactive Girls

MONIQUE ERNST, LAURA L. LIEBENAUER, A. CATHERINE KING, GLINDA A. FITZGERALD, ROBERT M. COHEN, ALAN J. ZAMETKIN

Research output: Contribution to journalArticle

Abstract

This study assesses the effect of attention-deficit hyperactivity disorder (ADHD) and gender on cerebral glucose metabolism (CMRglu), using positron emission tomography and 18F-fluorodeoxyglucose. Nineteen normal (6 females; 14.3 ± 1.3 years old) and 20 ADHD adolescents (5 females; 14.7 ± 1.6 years old) participated in the study. An auditory continuous performance task was used during the 30-minute uptake of 18F-fluorodeoxyglucose. There were no statistically significant differences in global or regional CMRglu between ADHD (N = 20) and normal (N = 19) adolescents. However, the global CMRglu in ADHD girls (N = 5) was 15.0% lower than in normal girls (N = 6) (p = .04), while global CMRglu in ADHD boys was not different than in normal boys. Furthermore, global CMRglu in ADHD girls was 19.6% lower than in ADHD boys (p = .02) and was not different between normal girls and normal boys. Clinical rating scales did not differentiate ADHD girls from ADHD boys, nor normal girls from normal boys. The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD.

Original languageEnglish (US)
Pages (from-to)858-868
Number of pages11
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume33
Issue number6
DOIs
StatePublished - Jan 1 1994

Keywords

  • adolescent
  • attention-deficit hyperactivity disorder
  • gender
  • glucose metabolism
  • positron emission tomography

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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