Reduced Brain Metabolism in Hyperactive Girls

MONIQUE ERNST; LAURA L. LIEBENAUER; A. CATHERINE KING; GLINDA A. FITZGERALD; ROBERT M. COHEN; ALAN J. ZAMETKIN

doi:10.1097/00004583-199407000-00012

Reduced Brain Metabolism in Hyperactive Girls

MONIQUE ERNST, LAURA L. LIEBENAUER, A. CATHERINE KING, GLINDA A. FITZGERALD, ROBERT M. COHEN, ALAN J. ZAMETKIN

School of Medicine

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

This study assesses the effect of attention-deficit hyperactivity disorder (ADHD) and gender on cerebral glucose metabolism (CMRglu), using positron emission tomography and ¹⁸F-fluorodeoxyglucose. Nineteen normal (6 females; 14.3 ± 1.3 years old) and 20 ADHD adolescents (5 females; 14.7 ± 1.6 years old) participated in the study. An auditory continuous performance task was used during the 30-minute uptake of ¹⁸F-fluorodeoxyglucose. There were no statistically significant differences in global or regional CMRglu between ADHD (N = 20) and normal (N = 19) adolescents. However, the global CMRglu in ADHD girls (N = 5) was 15.0% lower than in normal girls (N = 6) (p = .04), while global CMRglu in ADHD boys was not different than in normal boys. Furthermore, global CMRglu in ADHD girls was 19.6% lower than in ADHD boys (p = .02) and was not different between normal girls and normal boys. Clinical rating scales did not differentiate ADHD girls from ADHD boys, nor normal girls from normal boys. The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD.

Original language	English (US)
Pages (from-to)	858-868
Number of pages	11
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	33
Issue number	6
DOIs	https://doi.org/10.1097/00004583-199407000-00012
State	Published - 1994

Keywords

adolescent
attention-deficit hyperactivity disorder
gender
glucose metabolism
positron emission tomography

ASJC Scopus subject areas

Developmental and Educational Psychology
Psychiatry and Mental health

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10.1097/00004583-199407000-00012

Cite this

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title = "Reduced Brain Metabolism in Hyperactive Girls",

abstract = "This study assesses the effect of attention-deficit hyperactivity disorder (ADHD) and gender on cerebral glucose metabolism (CMRglu), using positron emission tomography and 18F-fluorodeoxyglucose. Nineteen normal (6 females; 14.3 ± 1.3 years old) and 20 ADHD adolescents (5 females; 14.7 ± 1.6 years old) participated in the study. An auditory continuous performance task was used during the 30-minute uptake of 18F-fluorodeoxyglucose. There were no statistically significant differences in global or regional CMRglu between ADHD (N = 20) and normal (N = 19) adolescents. However, the global CMRglu in ADHD girls (N = 5) was 15.0% lower than in normal girls (N = 6) (p = .04), while global CMRglu in ADHD boys was not different than in normal boys. Furthermore, global CMRglu in ADHD girls was 19.6% lower than in ADHD boys (p = .02) and was not different between normal girls and normal boys. Clinical rating scales did not differentiate ADHD girls from ADHD boys, nor normal girls from normal boys. The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD.",

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AU - COHEN, ROBERT M.

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AB - This study assesses the effect of attention-deficit hyperactivity disorder (ADHD) and gender on cerebral glucose metabolism (CMRglu), using positron emission tomography and 18F-fluorodeoxyglucose. Nineteen normal (6 females; 14.3 ± 1.3 years old) and 20 ADHD adolescents (5 females; 14.7 ± 1.6 years old) participated in the study. An auditory continuous performance task was used during the 30-minute uptake of 18F-fluorodeoxyglucose. There were no statistically significant differences in global or regional CMRglu between ADHD (N = 20) and normal (N = 19) adolescents. However, the global CMRglu in ADHD girls (N = 5) was 15.0% lower than in normal girls (N = 6) (p = .04), while global CMRglu in ADHD boys was not different than in normal boys. Furthermore, global CMRglu in ADHD girls was 19.6% lower than in ADHD boys (p = .02) and was not different between normal girls and normal boys. Clinical rating scales did not differentiate ADHD girls from ADHD boys, nor normal girls from normal boys. The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD.

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Reduced Brain Metabolism in Hyperactive Girls

Abstract

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