Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: Persistence of effect after partial volume correction

Carolyn Cidis Meltzer; Gwenn Smith; Julie C. Price; Charles F. Reynolds; Chester A. Mathis; Phil Greer; Brian Lopresti; Mark A. Mintun; Bruce G. Pollock; Doron Ben-Eliezer; Michael N. Cantwell; Walter Kaye; Steven T. Dekosky

doi:10.1016/S0006-8993(98)00909-3

Reduced binding of [¹⁸F]altanserin to serotonin type 2A receptors in aging: Persistence of effect after partial volume correction

Carolyn Cidis Meltzer, Gwenn Smith, Julie C. Price, Charles F. Reynolds, Chester A. Mathis, Phil Greer, Brian Lopresti, Mark A. Mintun, Bruce G. Pollock, Doron Ben-Eliezer, Michael N. Cantwell, Walter Kaye, Steven T. Dekosky

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

The serotonin (5-HT) neurotransmitter system, which has a widespread distribution in the central nervous system, has been implicated in regulating mood and many human behaviors. There is evidence from postmortem human studies and limited information from prior in vivo studies to support a decline in 5-HT2A receptor density with aging. We examined nine elderly (ages 61-76) and nine young (ages 18-29) healthy individuals with positron emission tomography (PET) and [¹⁸F]altanserin, a ligand with high affinity for the 5-HT2A binding site. The PET data were corrected for differences in brain tissue volume between the young and elderly subjects using a magnetic resonance (MR) imaging-based partial volume correction method. Highly significant and widespread cortical reductions in 5-HT2A specific binding were demonstrated in the elderly group relative to young controls. Regional losses averaged 61% before and 57% following correction for effects of cerebral atrophy. This finding, which is consistent with prior postmortem and in vivo studies, has both etiological and potential therapeutic implications for behavioral changes commonly observed in the elderly, including geriatric depression.

Original language	English (US)
Pages (from-to)	167-171
Number of pages	5
Journal	Brain research
Volume	813
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)00909-3
State	Published - Nov 30 1998
Externally published	Yes

Keywords

Aging
Emission tomography
Partial volume correction
Serotonin receptor

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(98)00909-3

Cite this

Meltzer, C. C., Smith, G., Price, J. C., Reynolds, C. F., Mathis, C. A., Greer, P., Lopresti, B., Mintun, M. A., Pollock, B. G., Ben-Eliezer, D., Cantwell, M. N., Kaye, W., & Dekosky, S. T. (1998). Reduced binding of [¹⁸F]altanserin to serotonin type 2A receptors in aging: Persistence of effect after partial volume correction. Brain research, 813(1), 167-171. https://doi.org/10.1016/S0006-8993(98)00909-3

Meltzer, CC, Smith, G, Price, JC, Reynolds, CF, Mathis, CA, Greer, P, Lopresti, B, Mintun, MA, Pollock, BG, Ben-Eliezer, D, Cantwell, MN, Kaye, W & Dekosky, ST 1998, 'Reduced binding of [¹⁸F]altanserin to serotonin type 2A receptors in aging: Persistence of effect after partial volume correction', Brain research, vol. 813, no. 1, pp. 167-171. https://doi.org/10.1016/S0006-8993(98)00909-3

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title = "Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: Persistence of effect after partial volume correction",

abstract = "The serotonin (5-HT) neurotransmitter system, which has a widespread distribution in the central nervous system, has been implicated in regulating mood and many human behaviors. There is evidence from postmortem human studies and limited information from prior in vivo studies to support a decline in 5-HT2A receptor density with aging. We examined nine elderly (ages 61-76) and nine young (ages 18-29) healthy individuals with positron emission tomography (PET) and [18F]altanserin, a ligand with high affinity for the 5-HT2A binding site. The PET data were corrected for differences in brain tissue volume between the young and elderly subjects using a magnetic resonance (MR) imaging-based partial volume correction method. Highly significant and widespread cortical reductions in 5-HT2A specific binding were demonstrated in the elderly group relative to young controls. Regional losses averaged 61% before and 57% following correction for effects of cerebral atrophy. This finding, which is consistent with prior postmortem and in vivo studies, has both etiological and potential therapeutic implications for behavioral changes commonly observed in the elderly, including geriatric depression.",

keywords = "Aging, Emission tomography, Partial volume correction, Serotonin receptor",

author = "Meltzer, {Carolyn Cidis} and Gwenn Smith and Price, {Julie C.} and Reynolds, {Charles F.} and Mathis, {Chester A.} and Phil Greer and Brian Lopresti and Mintun, {Mark A.} and Pollock, {Bruce G.} and Doron Ben-Eliezer and Cantwell, {Michael N.} and Walter Kaye and Dekosky, {Steven T.}",

note = "Funding Information: This work was supported by PHS grants AG5133 (Alzheimer's Disease Research Center), MH52247 (Mental Health Clinical Research Center for Late-Life Mood Disorders), MH49936, and MH01210, and the Radiological Society of North America Research and Education Fund. We also wish to thank N. Scott Mason, Daniel Holt and Norman Simpson for their contributions to this work.",

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T2 - Persistence of effect after partial volume correction

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AU - Smith, Gwenn

AU - Price, Julie C.

AU - Reynolds, Charles F.

AU - Mathis, Chester A.

AU - Greer, Phil

AU - Lopresti, Brian

AU - Mintun, Mark A.

AU - Pollock, Bruce G.

AU - Ben-Eliezer, Doron

AU - Cantwell, Michael N.

AU - Kaye, Walter

AU - Dekosky, Steven T.

N1 - Funding Information: This work was supported by PHS grants AG5133 (Alzheimer's Disease Research Center), MH52247 (Mental Health Clinical Research Center for Late-Life Mood Disorders), MH49936, and MH01210, and the Radiological Society of North America Research and Education Fund. We also wish to thank N. Scott Mason, Daniel Holt and Norman Simpson for their contributions to this work.

PY - 1998/11/30

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N2 - The serotonin (5-HT) neurotransmitter system, which has a widespread distribution in the central nervous system, has been implicated in regulating mood and many human behaviors. There is evidence from postmortem human studies and limited information from prior in vivo studies to support a decline in 5-HT2A receptor density with aging. We examined nine elderly (ages 61-76) and nine young (ages 18-29) healthy individuals with positron emission tomography (PET) and [18F]altanserin, a ligand with high affinity for the 5-HT2A binding site. The PET data were corrected for differences in brain tissue volume between the young and elderly subjects using a magnetic resonance (MR) imaging-based partial volume correction method. Highly significant and widespread cortical reductions in 5-HT2A specific binding were demonstrated in the elderly group relative to young controls. Regional losses averaged 61% before and 57% following correction for effects of cerebral atrophy. This finding, which is consistent with prior postmortem and in vivo studies, has both etiological and potential therapeutic implications for behavioral changes commonly observed in the elderly, including geriatric depression.

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