Reduced ascending aortic strain and distensibility: Earliest manifestations of vascular aging in humans

Alban Redheuil, Wen Chung Yu, Colin O. Wu, Elie Mousseaux, Alain De Cesare, Raymond Yan, Nadjia Kachenoura, David Bluemke, Joao Lima

Research output: Contribution to journalArticle

Abstract

Arterial stiffness predicts cardiovascular events beyond traditional risk factors. However, the relationship with aging of novel noninvasive measures of aortic function by MRI and their interrelationship with established markers of vascular stiffness remain unclear and currently limit their potential impact. Our aim was to compare age-related changes of central measures of aortic function with carotid distensibility, global carotid-femoral pulse wave velocity, and wave reflections. We determined aortic strain, distensibility, and aortic arch pulse wave velocity by MRI, carotid distensibility by ultrasound, and carotid-femoral pulse wave velocity by tonometry in 111 asymptomatic subjects (54 men, age range: 20 to 84 years). Central pressures were used to calculate aortic distensibility. Peripheral and central pulse pressure, augmentation index, and carotid-femoral pulse wave velocity increased with age, but aortic strain and aortic arch PWV were most closely and specifically related to aging. Ascending aortic (AA) strain and distensibility decreased, respectively, by 5.3±0.5% (R=0.54, P

Original languageEnglish (US)
Pages (from-to)319-326
Number of pages8
JournalHypertension
Volume55
Issue number2
DOIs
StatePublished - Feb 2010

    Fingerprint

Keywords

  • Aging
  • Aorta
  • Elasticity
  • MRI
  • Pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Redheuil, A., Yu, W. C., Wu, C. O., Mousseaux, E., De Cesare, A., Yan, R., Kachenoura, N., Bluemke, D., & Lima, J. (2010). Reduced ascending aortic strain and distensibility: Earliest manifestations of vascular aging in humans. Hypertension, 55(2), 319-326. https://doi.org/10.1161/HYPERTENSIONAHA.109.141275