Reduced antimicrobial peptide expression in human burn wounds

Stephen M. Milner, Marcos R. Ortega

Research output: Contribution to journalArticle

Abstract

Severely burned skin ceases to perform its natural protective role and surrenders itself as a nidus and portal for bacterial invasion. Antimicrobial peptides are part of a non-specific chemical defence system, separate from cellular and humoral immunity. Two of these peptides, human beta-defensins 1 and 2 have been recently found in skin and are produced by keratinocytes. Beta defensins have potent bactericidal activity against a wide spectrum of bacterial and fungal organisms commonly responsible for burn wound infections. To date, expression of beta defensins has not been examined in the human burn wound. Our findings demonstrate that expression of hBD-2 is greatly decreased in the burn wound whereas hBD-1 appears to be preserved. These results may have important implications in the pathogenesis and treatment of invasive burn sepsis.

Original languageEnglish (US)
Pages (from-to)411-413
Number of pages3
JournalBurns
Volume25
Issue number5
DOIs
StatePublished - Aug 1999
Externally publishedYes

Fingerprint

beta-Defensins
Skin
Peptides
Wounds and Injuries
Wound Infection
Humoral Immunity
Keratinocytes
Cellular Immunity
Sepsis
human DEFB4A protein
human DEFB1 protein

Keywords

  • Antimicrobial peptides
  • Burns
  • Sepsis

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Reduced antimicrobial peptide expression in human burn wounds. / Milner, Stephen M.; Ortega, Marcos R.

In: Burns, Vol. 25, No. 5, 08.1999, p. 411-413.

Research output: Contribution to journalArticle

Milner, Stephen M. ; Ortega, Marcos R. / Reduced antimicrobial peptide expression in human burn wounds. In: Burns. 1999 ; Vol. 25, No. 5. pp. 411-413.
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