Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia

Mizuho Takayanagi, Jacqueline Wentz, Yoichiro Takayanagi, David Schretlen, Elvan Ceyhan, Lei Wang, Michio Suzuki, Akira Sawa, Patrick Ernest Barta, J. Tilak Ratnanather, Nicola G. Cascella

Research output: Contribution to journalArticle

Abstract

Background: Patients with deficit schizophrenia (D-SZ) differ from patients with the non-deficit form of schizophrenia (ND-SZ) in several aspects such as risk factors, neurobiological correlates, treatment response and clinical outcome. It has been debated if brain morphology could differentiate D-SZ from ND-SZ. Anterior cingulate gyrus (ACG) region regulates cognitive and emotional processing and past studies reported structural changes in this region in patients with SZ. Methods: 1.5-T 3D MRI scans were obtained from 18 D-SZ patients, 30 ND-SZ patients and 82 healthy controls (HCs). We used FreeSurfer-initalized labeled cortical distance mapping (FSLCDM) to measure ACG gray matter volume, cortical thickness, and area of the gray/white interface. Furthermore, cortical thickness was compared among the 3 groups using the pooled labeled cortical distance mapping (LCDM) method. Results: The ACG cortex of the D-SZ group was thinner than the ND-SZ group. Pooled LCDM demonstrated that the ACG cortex was bilaterally thinner in both the ND-SZ group and the D-SZ group compared with the control group. The right ACG gray matter volume was significantly reduced in D-SZ patients as compared with healthy controls (p= 0.005. Conclusion: Our data suggest that qualitative, categorical differences in neuroanatomy may distinguish between deficit and non-deficit subtypes of schizophrenia.

Original languageEnglish (US)
Pages (from-to)484-490
Number of pages7
JournalSchizophrenia Research
Volume150
Issue number2-3
DOIs
StatePublished - Nov 2013

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Gyrus Cinguli
Schizophrenia
Gray Matter
Neuroanatomy
Magnetic Resonance Imaging

Keywords

  • Anterior cingulate cortex
  • Cortical thickness
  • Deficit schizophrenia
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia. / Takayanagi, Mizuho; Wentz, Jacqueline; Takayanagi, Yoichiro; Schretlen, David; Ceyhan, Elvan; Wang, Lei; Suzuki, Michio; Sawa, Akira; Barta, Patrick Ernest; Ratnanather, J. Tilak; Cascella, Nicola G.

In: Schizophrenia Research, Vol. 150, No. 2-3, 11.2013, p. 484-490.

Research output: Contribution to journalArticle

Takayanagi, M, Wentz, J, Takayanagi, Y, Schretlen, D, Ceyhan, E, Wang, L, Suzuki, M, Sawa, A, Barta, PE, Ratnanather, JT & Cascella, NG 2013, 'Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia', Schizophrenia Research, vol. 150, no. 2-3, pp. 484-490. https://doi.org/10.1016/j.schres.2013.07.036
Takayanagi, Mizuho ; Wentz, Jacqueline ; Takayanagi, Yoichiro ; Schretlen, David ; Ceyhan, Elvan ; Wang, Lei ; Suzuki, Michio ; Sawa, Akira ; Barta, Patrick Ernest ; Ratnanather, J. Tilak ; Cascella, Nicola G. / Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia. In: Schizophrenia Research. 2013 ; Vol. 150, No. 2-3. pp. 484-490.
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