Reduced albumin levels and utilization of arteriovenous access in pediatric patients with systemic lupus erythematosus (SLE)

Sangeeta Sule, Jeffrey J. Fadrowski, Barbara A Fivush, Gregory Gorman, Susan L. Furth

Research output: Contribution to journalArticle

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects between five and ten thousand children in the USA. Kidney disease may progress to end-stage renal disease (ESRD) and subsequent need for dialysis therapy in a significant number of children with SLE. We performed a cross-sectional analysis comparing achievement of National Kidney Foundation/Kidney Disease Outcomes Quality Initiative clinical targets in pediatric patients with SLE maintained on hemodialysis (HD) to pediatric patients with other causes of ESRD. Ninety-seven unique SLE patients and two control groups - 1,823 unique pediatric patients with other causes of ESRD and 694 pediatric patients with glomerulonephritis - were identified in the End Stage Renal Disease Clinical Performance Measures 2000-2004 Project Years. SLE patients were older, with a female and black race predominance compared with both control groups. Pediatric patients maintained on HD secondary to SLE were less likely to meet albumin targets and more likely to have vascular catheters than were pediatric patients on HD secondary to other causes. These findings may be associated with increased morbidity and mortality in pediatric patients with SLE maintained on HD and deserve further study.

Original languageEnglish (US)
Pages (from-to)2041-2046
Number of pages6
JournalPediatric Nephrology
Volume22
Issue number12
DOIs
StatePublished - Dec 2007

Fingerprint

Systemic Lupus Erythematosus
Albumins
Pediatrics
Chronic Kidney Failure
Renal Dialysis
Kidney Diseases
Vascular Access Devices
Control Groups
Glomerulonephritis
Autoimmune Diseases
Dialysis
Cross-Sectional Studies
Morbidity
Kidney
Mortality

Keywords

  • Albumin
  • Dialysis
  • Pediatrics
  • Systemic lupus erythematosus
  • Vascular access

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Reduced albumin levels and utilization of arteriovenous access in pediatric patients with systemic lupus erythematosus (SLE). / Sule, Sangeeta; Fadrowski, Jeffrey J.; Fivush, Barbara A; Gorman, Gregory; Furth, Susan L.

In: Pediatric Nephrology, Vol. 22, No. 12, 12.2007, p. 2041-2046.

Research output: Contribution to journalArticle

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