Redox responses in patients with sepsis: High correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels

Thorsten Brenner, Claudia Rosenhagen, Jochen Steppan, Christoph Lichtenstern, Jürgen Weitz, Thomas Bruckner, Eike O. Martin, Ursula Hoffmann, Markus A. Weigand, Stefan Hofer

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n=15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n=18) were collected once; samples from postoperative patients (n=28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: r sp =0.720,=0.698/t24: r sp =0.771,=0.949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/ ~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.

Original languageEnglish (US)
Article number985614
JournalMediators of inflammation
Volume2010
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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