TY - JOUR
T1 - Redox responses in patients with sepsis
T2 - High correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels
AU - Brenner, Thorsten
AU - Rosenhagen, Claudia
AU - Steppan, Jochen
AU - Lichtenstern, Christoph
AU - Weitz, Jürgen
AU - Bruckner, Thomas
AU - Martin, Eike O.
AU - Hoffmann, Ursula
AU - Weigand, Markus A.
AU - Hofer, Stefan
PY - 2010
Y1 - 2010
N2 - Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n=15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n=18) were collected once; samples from postoperative patients (n=28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: r sp =0.720,=0.698/t24: r sp =0.771,=0.949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/ ~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.
AB - Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n=15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n=18) were collected once; samples from postoperative patients (n=28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: r sp =0.720,=0.698/t24: r sp =0.771,=0.949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/ ~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.
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U2 - 10.1155/2010/985614
DO - 10.1155/2010/985614
M3 - Article
C2 - 20847814
AN - SCOPUS:77956812317
SN - 0962-9351
VL - 2010
JO - Mediators of inflammation
JF - Mediators of inflammation
M1 - 985614
ER -