Redox Reactions of Hemoglobin

Joseph M. Rifkind, Somasundaram Ramasamy, P. T. Manoharan, Nagababu Enika, Joy G. Mohanty

Research output: Contribution to journalArticle

Abstract

Redox reactions of hemoglobin have gained importance because of the general interest of the role of oxidative stress in diseases and the possible role of red blood cells in oxidative stress. Although electron paramagnetic resonance (EPR) is extremely valuable in studying hemoglobin redox reactions it has not been adequately used. We have focused in this review on the important contributions of EPR to our understanding of hemoglobin redox reactions. We have limited our discussion to the redox reactions thought to occur under physiological conditions. This includes autoxidation as well as the reactions of hydrogen peroxide generated by superoxide dismutation. We have also discussed redox reactions associated with nitric oxide produced in the circulation. We have pinpointed the value of using EPR to detect and study the paramagnetic species and free radicals formed during these reactions. We have shown how EPR not only identifies the paramagnetic species formed but can also be used to provide insights into the mechanism involved in the redox reactions.

Original languageEnglish (US)
Pages (from-to)657-666
Number of pages10
JournalAntioxidants and Redox Signaling
Volume6
Issue number3
StatePublished - Jun 2004
Externally publishedYes

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Redox reactions
Oxidation-Reduction
Hemoglobins
Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Oxidative stress
Oxidative Stress
Superoxides
Hydrogen Peroxide
Free Radicals
Nitric Oxide
Blood
Erythrocytes
Cells

ASJC Scopus subject areas

  • Biochemistry

Cite this

Rifkind, J. M., Ramasamy, S., Manoharan, P. T., Enika, N., & Mohanty, J. G. (2004). Redox Reactions of Hemoglobin. Antioxidants and Redox Signaling, 6(3), 657-666.

Redox Reactions of Hemoglobin. / Rifkind, Joseph M.; Ramasamy, Somasundaram; Manoharan, P. T.; Enika, Nagababu; Mohanty, Joy G.

In: Antioxidants and Redox Signaling, Vol. 6, No. 3, 06.2004, p. 657-666.

Research output: Contribution to journalArticle

Rifkind, JM, Ramasamy, S, Manoharan, PT, Enika, N & Mohanty, JG 2004, 'Redox Reactions of Hemoglobin', Antioxidants and Redox Signaling, vol. 6, no. 3, pp. 657-666.
Rifkind JM, Ramasamy S, Manoharan PT, Enika N, Mohanty JG. Redox Reactions of Hemoglobin. Antioxidants and Redox Signaling. 2004 Jun;6(3):657-666.
Rifkind, Joseph M. ; Ramasamy, Somasundaram ; Manoharan, P. T. ; Enika, Nagababu ; Mohanty, Joy G. / Redox Reactions of Hemoglobin. In: Antioxidants and Redox Signaling. 2004 ; Vol. 6, No. 3. pp. 657-666.
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