Redox and nitrosative regulation of cardiac remodeling

David A. Kass, Ajay M. Shah

Research output: Contribution to journalReview articlepeer-review

Abstract

Heart disease is a major cause of death and morbidity worldwide, particularly so in industrialized nations. A major contributor to its varied pathophysiology is abnormal oxidative/reductive and nitrosative stress. While oxidant-scavenging therapies for cardiovascular disease have been disappointing to date, new insights into the precise sources of oxidative/nitrosative stress, its compartmentalized targets, and the modulators designed to control it are paving the way for a very different approach. This issue of the journal presents a Forum highlighting recent work from an international network of investigators that focuses on the role of oxidative/nitrosative stress in the remodeling heart.

Original languageEnglish (US)
Pages (from-to)1021-1023
Number of pages3
JournalAntioxidants and Redox Signaling
Volume18
Issue number9
DOIs
StatePublished - Mar 20 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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