Redox and nitrosative regulation of cardiac remodeling

David A Kass, Ajay M. Shah

Research output: Contribution to journalArticle

Abstract

Heart disease is a major cause of death and morbidity worldwide, particularly so in industrialized nations. A major contributor to its varied pathophysiology is abnormal oxidative/reductive and nitrosative stress. While oxidant-scavenging therapies for cardiovascular disease have been disappointing to date, new insights into the precise sources of oxidative/nitrosative stress, its compartmentalized targets, and the modulators designed to control it are paving the way for a very different approach. This issue of the journal presents a Forum highlighting recent work from an international network of investigators that focuses on the role of oxidative/nitrosative stress in the remodeling heart.

Original languageEnglish (US)
Pages (from-to)1021-1023
Number of pages3
JournalAntioxidants and Redox Signaling
Volume18
Issue number9
DOIs
StatePublished - Mar 20 2013

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Oxidative stress
Oxidation-Reduction
Oxidative Stress
Scavenging
Developed Countries
Oxidants
Modulators
Cause of Death
Heart Diseases
Cardiovascular Diseases
Research Personnel
Morbidity
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Redox and nitrosative regulation of cardiac remodeling. / Kass, David A; Shah, Ajay M.

In: Antioxidants and Redox Signaling, Vol. 18, No. 9, 20.03.2013, p. 1021-1023.

Research output: Contribution to journalArticle

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